NAD-Boosting Anti-Aging Composition for Enzyme Saturation Limits

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Solution Overview

Problem

Existing NAD precursor supplementation methods for anti-aging are expensive, inefficient, and face saturation issues, leading to limited NAD concentration enhancement in humans, with potential diminishing efficacy over time.

Innovation Solution

A novel composition combining a NAD precursor with a NAMPT upregulator, NQO1 upregulator, and optionally a NNMT downregulator, which can be administered separately or together, to enhance NAD concentrations in mammals.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Quantity of substance

If high doses of NAD precursors are administered to humans, then NAD concentration enhancement is achieved, but saturation of enzymes and excretion of surplus precursor occurs, leading to diminishing returns

Engineering Contradiction:

ImproveNAD concentration enhancementVSAvoidefficacy stability over time

Core Design Contradiction:

Quantity of substanceVSReliability

Solution Approach 1:

The invention changes the approach from increasing precursor quantity to modulating enzyme activity parameters. By using NAMPT upregulators and NQO1 upregulators, the system optimizes the catalytic efficiency and expression levels of key enzymes in the NAD synthesis pathway, achieving sustained NAD enhancement without saturation effects

Inventive Principle:

Principle #35Parameter changes

Solution Approach 2:

The composition includes agents that respond to cellular NAD status and regulate enzyme activity accordingly. NAMPT upregulators and NQO1 upregulators create a feedback mechanism where enzyme expression is modulated based on metabolic needs, preventing saturation and maintaining efficacy over time

Inventive Principle:

Principle #23Feedback

2Quantity of substance

If NAD precursor supplementation is scaled up to human doses, then the cost increases significantly

Engineering Contradiction:

ImproveNAD concentration enhancementVSAvoidcost

Core Design Contradiction:

Quantity of substanceVSEase of manufacture

Solution Approach 1:

The invention introduces intermediary substances (NAMPT upregulators and NQO1 upregulators) that act as catalysts to enhance NAD production. These agents amplify the effectiveness of smaller amounts of NAD precursors, reducing the total quantity of expensive precursor material needed while achieving the same therapeutic effect

Inventive Principle:

Principle #24Intermediary (Mediator)

Solution Approach 2:

By changing from a quantity-based approach to an activity-based approach, the invention reduces material consumption. Upregulating enzyme parameters allows the system to produce more NAD per unit of precursor, thereby reducing the cost of goods sold while maintaining efficacy

Inventive Principle:

Principle #35Parameter changes

3Device complexity

If only NAD precursors are used, then the system is simple, but enzyme saturation limits further NAD enhancement

Engineering Contradiction:

Improvecomposition simplicityVSAvoidNAD concentration enhancement

Core Design Contradiction:

Device complexityVSQuantity of substance

Solution Approach 1:

The invention merges multiple functional components into a single composition: NAD precursors, NAMPT upregulators, and NQO1 upregulators work synergistically. This combination addresses the saturation problem by enhancing enzyme capacity while providing substrate, achieving greater NAD enhancement than any single component alone

Inventive Principle:

Principle #5Merging (Combining)

Solution Approach 2:

The composition functions as a composite system where different agents target different steps in the NAD synthesis pathway. By combining precursors with enzyme upregulators, the system creates a multi-component formulation that overcomes the limitations of single-component approaches

Inventive Principle:

Principle #40Composite materials

Data Source

PatentUS12551462B2Anti-aging composition with rutin, apigenin, epigallocatechin gallate, lipoic acid and the NAD precursor, niacinamide

Publication Date: 2026.02.17 NUCHIDO LTD

AI summary

There is described a composition comprising an effective amount of a combination of two or more components selected from a NAD precursor; a NAMPT upregulator; a NQO1 upregulator and a NNMT (nicotinamide N-methyltransferase) downregulator.