Nano Lipid Delivery System for Agricultural Chemistry Translocation
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Solution Overview
Problem
Existing agricultural chemistry delivery systems face challenges in achieving efficient absorption, translocation, and stability, often compromised by environmental factors and interference with plant processes.
Innovation Solution
A nano lipid delivery system comprising a nano-particle concentrate with a lipid, oil, or solvent having specific solvency and viscosity properties, combined with amphipathic compounds, to form a stable nano emulsion with particle sizes under 100 nm for enhanced delivery.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional delivery systems (liposomes formed by mechanical agitation) are used, then delivery of agricultural chemistries is achieved, but the systems are heterogeneous in size and have limited stability/shelf-life
Solution Approach 1:
The patent changes the physical and chemical parameters of the delivery system by using specifically selected lipids with defined chain lengths (C10-C22), degrees of unsaturation, and ratios (e.g., saturated to unsaturated lipid ratios). It also controls particle size parameters to achieve monodisperse systems with narrow size distributions (PDI < 0.1), transforming the conventional heterogeneous liposome systems into uniform nano-sized delivery vehicles with improved stability.
Solution Approach 2:
The patent creates composite delivery systems by combining multiple lipid components with specific properties (saturated and unsaturated lipids in defined ratios), along with complementary non-lipid components. This composite approach allows the system to achieve both monodispersity and enhanced stability, overcoming the limitations of single-component liposome systems.
2Ease of manufacture
If lipid to lipid products are used for cuticle penetration and wetting, then adherence to plant surface is improved, but they interfere with respiration, xylem and phloem translocation
Solution Approach 1:
The patent applies local quality by creating amphiphilic molecules with distinct hydrophobic and hydrophilic regions. The hydrophobic portion interacts with the cuticle for penetration, while the hydrophilic portion remains in the aqueous phase, allowing the molecule to function as a penetration promoter without blocking plant translocation pathways. This localized functional differentiation resolves the contradiction between penetration efficacy and translocation interference.
Solution Approach 2:
The amphiphilic molecules act as intermediaries that facilitate cuticle penetration without directly interfering with plant physiology. These molecules mediate the interaction between the agricultural chemistry and the plant cuticle, enabling adhesion and penetration while maintaining compatibility with plant respiration and translocation processes.
3Productivity
If agricultural chemistries are applied and need quick translocation, then efficacy is improved, but environmental factors (rain, sunlight, humidity, temperature) reduce absorption if taken too long
Solution Approach 1:
The patent employs preliminary action by pre-forming the agricultural chemistry within the amphiphilic molecule structure before application. The chemistry is incorporated into the hydrophobic region of the amphiphilic molecule during formulation, ensuring it is already positioned for rapid translocation upon contact with plant tissues, thereby eliminating delays that would expose it to environmental degradation.
Solution Approach 2:
The amphiphilic molecules provide self-service by automatically directing the agricultural chemistry to the cuticle interface through their inherent structural properties. The hydrophobic region naturally interacts with the cuticle while the hydrophilic region remains in the aqueous phase, creating a self-assembling delivery mechanism that requires no additional energy input or external intervention for rapid translocation.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The nano lipid delivery system improves the absorption and translocation of agricultural chemistries, reducing environmental impact and increasing efficacy by ensuring stable and targeted delivery to plant tissues.
Implementation Method 1
at least one amphipathic compound selected from the group consisting of an alkoxylated lipid, an alkoxylated fatty acid, an alkoxylated alcohol, a heteroatomic hydrophilic lipid, a heteroatomic hydrophilic fatty acid, a heteroatomic hydrophilic alcohol or a combination of any of these compounds
Implementation Method 2
the resulting concentrate providing a stable nano emulsion having a particle size distribution of D50 and a mean average particle size distribution of less than 100 nm when diluted with water
Implementation Method 3
Nano-capsules can enable effective penetration of the substance through cuticles and tissues
Implementation Method 4
The efficacy of agricultural chemistries such as pesticides, stimulants, desiccants, plant grow regulators and or nutrients are determined by the dispersion, absorption, translocation, metabolism and mode of action in the target pest or plant
Implementation Method 5
Once absorbed, sufficient agricultural chemistries, or their active ingredients, typically need to be quickly translocated from the point of application to the preferred site of action within, or on the target
Implementation Method 6
they can interfere with respiration, xylem and especially phloem translocation
Data Source
AI summary
A nano lipid delivery system including a nano concentrate, a nano-lipid stable emulsion, a method of preparing a nano lipid concentrate and lipid delivery system for use as a carrier for industrial, medical, animal, horticultural and agricultural chemistries.