Nano-Liposomal Nutrient Delivery for Solubility and Stability
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Solution Overview
Problem
Conventional nutritional supplements face challenges in delivering hydrophobic nutraceuticals due to poor solubility, stability, and oxidation sensitivity, leading to complex and expensive production methods, and the need for unnecessary additives.
Innovation Solution
A nano-scale composite particle system encapsulating vitamins like sodium ascorbate, methylcobalamine, pyridoxine, and pantothenic acid within a stabilized and sealed H2O molecule, which is colorless, odorless, and tasteless, ensuring stability and bioavailability when dispersed in aqueous media.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Stability of the object's composition
If hydrophobic nutraceuticals are delivered using conventional systems, then solubility is improved through surfactants, but product complexity and cost increase
Solution Approach 1:
The patent uses composite liposomal structures combining phospholipids with hydrophobic nutraceuticals, creating a unified delivery system that inherently provides both solubility and stability without requiring additional surfactants or complex formulations
Solution Approach 2:
The patent transforms the physical state and surface properties of nutraceuticals by encapsulating them in liposomal vehicles, changing their effective solubility parameters and allowing them to disperse stably in aqueous media without conventional surfactants
2Stability of the object's composition
If hydrophobic nutraceuticals are encapsulated in nano vehicles, then solubility is improved, but colloidal stability becomes challenging
Solution Approach 1:
The patent employs flexible liposomal membranes that can adapt to environmental conditions while maintaining structural integrity, providing colloidal stability through the natural surfactant properties of phospholipids that form stable bilayer structures
Solution Approach 2:
The liposomal structure acts as an intermediary between hydrophobic nutraceuticals and aqueous media, with the phospholipid bilayer serving as a stable interface that prevents aggregation and maintains colloidal stability throughout shelf life
3Ease of manufacture
If nutraceuticals are delivered in larger particles, then production is simpler, but turbidity increases
Solution Approach 1:
The patent divides nutraceuticals into discrete nano-sized liposomal particles, creating uniformly small structures that remain transparent in solution while maintaining ease of production through standardized liposomal formation processes
Solution Approach 2:
The patent transitions from macroscopic or microparticulate delivery systems to the nanoscale dimension, where particles become small enough to eliminate light scattering and turbidity while maintaining manufacturing simplicity through self-assembly mechanisms
4Ease of manufacture
If conventional delivery systems are used, then production cost is lower, but oxidation protection is insufficient
Solution Approach 1:
The liposomal interior creates a protected, oxygen-excluded environment for encapsulated nutraceuticals, effectively isolating them from oxidative degradation while maintaining cost-effectiveness through the use of natural phospholipid materials
Solution Approach 2:
The patent converts the natural amphiphilic properties of phospholipids, which normally require stabilization against oxidation, into a protective mechanism where the liposomal structure itself provides the oxidation barrier, transforming a potential vulnerability into a protective feature
Data Source
AI summary
A nano solid liquid H2O concentrate and method, the concentrate containing molecules of H2O each encapsulating a composite nano particle including selected nutrient particles of nano scale, the composite particles each having a size generally within a range of 12 and 16 nanometers, a bond between the composite particles and respective interior and/or exterior layers of the H2O molecule being stabilized and sealed.