Nanoparticle Pharmaceutical Coating for Solubility
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Solution Overview
Problem
Existing pharmaceutical formulations face challenges in enhancing the bioavailability and solubility of therapeutic agents, which are crucial for effective disease treatment.
Innovation Solution
A process involving milling a pharmaceutical composition in a ball milling apparatus to produce nanoparticle form, followed by coating with one or more polymers, to enhance bioavailability and solubility.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Quantity of substance
If the particle size of the pharmaceutical composition is reduced to nanoparticle form, then the solubility and bioavailability of the therapeutic agent is significantly increased, but the manufacturing complexity and equipment requirements are increased
Solution Approach 1:
The pharmaceutical composition is segmented into nanoparticle form through ball milling, dividing the bulk material into numerous fine particles. This segmentation dramatically increases the total surface area and solubility of the therapeutic agent while maintaining the same chemical composition, thereby resolving the contradiction between particle size reduction and manufacturing feasibility
Solution Approach 2:
The patent introduces an intermediary coating layer around the nanoparticles to stabilize them and prevent aggregation. This coating acts as a mediator that maintains nanoparticle dispersion and solubility benefits while enabling practical manufacturing and storage, thus resolving the complexity issue associated with nanoparticle production
2Area of stationary object
If ball milling is used to reduce particle size to nanoparticle form, then the surface area and solubility are dramatically increased, but the energy consumption and processing time are increased
Solution Approach 1:
The ball milling process is designed with preliminary considerations for energy efficiency, including optimizing ball size distribution, mill speed, and milling time to achieve nanoparticle formation with minimal energy input. The process parameters are pre-optimized to reach the desired nanoparticle size range without excessive energy consumption or prolonged processing time
Solution Approach 2:
The patent employs parameter changes during the milling process, such as varying mill speed, ball-to-powder ratio, and milling duration, to achieve efficient nanoparticle formation. By dynamically adjusting these parameters, the process maximizes surface area generation while minimizing energy consumption and processing time
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The process significantly increases the bioavailability and solubility of therapeutic agents by 2 to 20 folds, leading to improved therapeutic outcomes.
Implementation Method 1
milling a pharmaceutical composition in a ball milling apparatus to produce a nanoparticle form of the pharmaceutical composition
Implementation Method 2
coating the nanoparticle form of the pharmaceutical composition with one or more polymers
Data Source
AI summary
This invention relates to methods of preparing nanotherapeutic compounds and compositions comprising nanotherapeutic compounds. The nanotherapeutic compounds prepared according to the methods provided herein are useful for the treatment of disease, for example, cancer, in a subject in need thereof.