Nanocapsule Shell Hydrogel Formation via Modified Nucleobases
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Solution Overview
Problem
Current drug delivery systems in pharmaceutical formulations often rely on synthetic or natural polymers for gel formation, leading to increased systemic toxicity and complexity, particularly in cancer treatment, where there is a need for safer, locally delivered, and sustained release formulations with a limited number of excipients.
Innovation Solution
The development of modified nucleobases, nucleosides, deoxynucleosides, and their derivatives that spontaneously form hydrogels and oleogels without additional gelling agents, allowing for the creation of nanoparticles-based gel systems for localized and sustained release of active ingredients.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Stability of the object's composition
If synthetic or natural polymers are added to induce gelation, then gel formation is achieved, but the number of excipients increases and systemic toxicity may increase
Solution Approach 1:
The patent extracts and eliminates the need for external gelling agents (polymers) by incorporating gelling capability directly into the nanocapsule shell through modified nucleobases. This removes the separate polymer excipient component while maintaining gel formation function.
Solution Approach 2:
The nanocapsule shell is designed to perform multiple functions: it provides drug encapsulation, structural stability, and gelling activity. The modified nucleobase in the shell serves both as a structural component and as the gelling agent, eliminating the need for separate excipients.
2Stability of the object's composition
If synthetic or natural polymers are added to induce gelation, then gel formation is achieved, but additional side effects may occur
Solution Approach 1:
The nanocapsule shell serves itself by providing both structural function and gelling function. The modified nucleobase in the shell automatically provides gelling capability without requiring external polymer additives, thereby avoiding the toxic side effects associated with synthetic or natural polymers.
Solution Approach 2:
The patent changes the chemical composition parameters of the nanocapsule shell by incorporating modified nucleobases with specific functional groups that enable gelling. This compositional change eliminates the need for toxic polymer excipients while maintaining effective gel formation.
3Stability of the object's composition
If nanoparticles are dispersed in polymeric matrix without interaction, then gel-based systems are formed, but nanoparticles are released by diffusion or erosion without controlled interaction
Solution Approach 1:
The patent merges the nanocapsule shell with the gelling network by making the shell itself the gelling component. The modified nucleobases in the shell form hydrogen bonds that create the gel network, so the nanoparticles are integrated into the gel structure through their shell rather than being merely dispersed in a separate polymeric matrix.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
These systems enable safe and efficient delivery of both hydrophilic and lipophilic active ingredients, such as anticancer drugs, without residual polymeric matrices, facilitating local administration and sustained release, particularly in cancer and vascular disease treatments.
Implementation Method 1
the compounds of formula (A) are localized at the oil-in-water interface between the nanocapsules and the aqueous medium and that they are exposed to water (i.e. they are in the external side of the shell of the nanocapsules). This particular assembly promotes inter-nanocapsules interactions via hydrogen bonds between the compounds of formula (A), that leads to a nanocapsules-based hydrogel structure.
Implementation Method 2
the compounds of formula (A) are localized at the oil-in-water interface between the nanocapsules and the aqueous medium
Data Source
AI summary
The present invention concerns modified nucleobases, nucleosides, deoxynucleosides, and/or their derivatives, nanocapsules comprising them, hydrogels and oleogels comprising said nanocapsules or said above-mentioned compounds and their uses, in particular their pharmaceutical uses.