Biodegradable Nanocomposite Implant for Targeted Bone Regeneration
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Solution Overview
Problem
Current surgical procedures for addressing skeletal deficiencies, such as bone trauma, tumors, and diseases, often require multiple interventions and have limitations in effectively restoring normal bone function and tissue regeneration.
Innovation Solution
A biocompatible structure composed of biodegradable and bioresorbable nanocomposite materials, specifically formed by alternating layers of polymers and spacer particles, which are designed to match the specific properties of different tissues at an implant site, facilitating targeted regeneration through controlled degradation and bioactive material delivery.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If traditional surgical procedures are used to address skeletal deficiencies, then bone function can be restored, but multiple interventions are required and tissue regeneration is limited
Solution Approach 1:
The implant is divided into multiple alternating layers of biodegradable polymer and bioactive material (such as hydroxyapatite or demineralized bone matrix), creating a segmented structure that provides both mechanical support and biological functionality in a single intervention
Solution Approach 2:
The invention uses composite materials combining biodegradable polymers with bioactive substances to create an implant that simultaneously provides structural integrity and promotes tissue regeneration, eliminating the need for multiple separate procedures
2Adaptability or versatility
If biodegradable nanocomposite materials are used, then targeted tissue regeneration is enabled, but the structure must match specific tissue properties
Solution Approach 1:
Different layers of the implant have different compositions and degradation rates tailored to match specific tissue types at the implant site, with each layer providing localized functionality for targeted regeneration of bone, muscle, or other tissues
Solution Approach 2:
The degradation rate, porosity, and mechanical properties of each layer are adjusted as parameters to match the specific requirements of different tissues, allowing the same basic structure to be adapted for various regeneration applications
3Duration of action of moving object
If alternating layers of polymer and spacer particles are used, then degradation rate can be matched to tissue type, but manufacturing process becomes complex
Solution Approach 1:
The implant is manufactured using a periodic layering process where polymer solution and spacer particle suspension are alternately deposited to form repeating layers with controlled thickness and composition, enabling precise degradation rate control through systematic variation of layer parameters
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The structure enables efficient and targeted tissue regeneration by matching the degradation rate and properties of the biocompatible layers to the specific tissue type, promoting effective bone and muscle regeneration while minimizing surgical intervention.
Implementation Method 1
Each of the polymer layers is formed with a polymer and tissue forming nanoparticles... controlled degradation
Implementation Method 2
sonicating the second solution to uniformly distribute the first polymer and the first tissue forming nanoparticles in the second solution
Implementation Method 3
drying the second solution on the first surface to form the first polymer film on the first surface
Data Source
AI summary
A biocompatible structure includes one or more base structures for regeneration of different tissues. Each base structure includes alternately stacked polymer layers and spacer layers. The polymer layer includes a polymer and tissue forming nanoparticles. The polymer includes polyurethane. The tissue forming nanoparticles includes hydroxypatites (HAP) nanoparticles, polymeric nanoparticles, or nanofibers. The spacer layer includes bone particles, polymeric nanoparticles, or nanofibers. The weight percentage of tissue forming nanoparticles to the polymer in the polymer layer in one base structure is different from that in the other base structures. A method of producing the biocompatible structure includes forming multiple base structures stacked together, coating the stacked multiple base structures, and plasma treating the coated structure.