Non-enzymatic Nanocomposite Sensor for Real-time Analyte Detection
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Solution Overview
Problem
Current technologies for detecting post-operative complications such as anastomotic leakage are nonspecific, inefficient, time-consuming, and lack real-time detection capabilities, often relying on costly and invasive methods like CT scans and blood tests.
Innovation Solution
A non-enzymatic sensor device using self-assembled nanocomposite chains with metal domains is developed for continuous, real-time monitoring of analytes like glucose and lactate in biofluids, capable of operating in isotonic and physiological pH conditions.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If traditional diagnostic techniques (CT scans, MRIs, blood tests) are used to detect post-operative complications, then diagnostic accuracy can be achieved, but the detection process becomes time-consuming and costly
Solution Approach 1:
The patent replaces complex mechanical and chemical diagnostic systems (CT scanners, MRI machines, laboratory blood tests) with an electrochemical sensor system that uses electrical signals to detect analyte concentrations. The sensor device with working, reference, and counter electrodes performs rapid electrochemical measurements that substitute for time-consuming traditional diagnostic equipment while maintaining diagnostic accuracy for detecting post-operative complications
Solution Approach 2:
The patent creates a simplified model system that copies the essential diagnostic function of traditional methods. Instead of using complex imaging and laboratory analysis, the sensor device creates an electrochemical model of the patient's physiological state by measuring analyte concentrations (glucose, lactate, pH) that indicate complications, providing a rapid copy of diagnostic information without the time and cost of original diagnostic procedures
2Reliability
If traditional diagnostic methods are used, then comprehensive analysis can be performed, but the methods lack real-time detection capability and require invasive procedures
Solution Approach 1:
The sensor device performs self-service by autonomously measuring analyte concentrations in peritoneal fluid without requiring continuous human intervention or complex diagnostic equipment. The device with its electrode assembly continuously monitors glucose, lactate, and pH levels, automatically detecting complications and alerting medical staff, thereby making the diagnostic process easier and less invasive while maintaining reliable real-time detection capability
Solution Approach 2:
The patent introduces peritoneal fluid as an intermediary medium that provides access to diagnostic information without requiring invasive blood draws or complex imaging procedures. The sensor device measures analyte concentrations in this intermediate fluid, which reflects the patient's physiological state and indicates complications, thereby simplifying the diagnostic process while maintaining detection reliability
3Measurement precision
If enzyme-based sensors are used for analyte detection, then specific and sensitive detection can be achieved, but the sensors lack stability and cannot provide continuous long-term monitoring
Solution Approach 1:
The patent changes the fundamental parameter of the sensing mechanism from enzymatic to non-enzymatic electrochemical detection. By using metal-based electrocatalytic materials instead of enzymes, the system eliminates the stability limitations of biological catalysts while maintaining detection sensitivity through electrochemical measurements of analyte oxidation and reduction reactions at the electrode surfaces
Solution Approach 2:
The patent employs composite electrochemical sensor materials that combine different metal oxides and conductive materials to achieve both sensitivity and stability. The working electrodes use composite structures with metal oxide catalysts supported on conductive substrates, providing enhanced catalytic activity for analyte detection while ensuring long-term operational stability for continuous monitoring applications
4Measurement precision
If frequent monitoring is performed to enable early detection, then complication detection accuracy improves, but resource consumption and patient burden increase
Solution Approach 1:
The sensor device enables continuous autonomous monitoring of multiple analytes (glucose, lactate, pH) in peritoneal fluid without requiring repeated invasive sampling or consumption of expensive diagnostic resources. The single sensor implant performs self-service by continuously measuring analyte concentrations and detecting complications early, thereby improving detection accuracy while minimizing resource consumption compared to frequent traditional diagnostic procedures
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The sensor device provides early and accurate detection of post-surgical complications by continuously monitoring lactate and glucose levels, potentially reducing morbidity and mortality by enabling timely interventions.
Implementation Method 1
each of the one or more working electrodes comprising a plurality of self-assembled nanocomposite chains having metal domains deposited on a substrate of each of the one or more working electrodes
Implementation Method 2
measuring electron transfer through enzyme-catalyzed processes involving the target analyte
Implementation Method 3
measuring electron transfer through enzyme-catalyzed processes involving the target analyte
Data Source
AI summary
The present disclosure describes various embodiments of devices, systems, and methods for analyte detection using non-enzymatic sensors. In one embodiment, there is disclosed sensor device for detecting one or more analytes, the sensor device comprising: one or more working electrodes, each of the one or more working electrodes comprising a plurality of reduced or oxidized nanocomposite chains having metal domains deposited on a substrate of each of the one or more working electrodes; a reference electrode and a counter electrode, connected, by a circuit, to the one or more working electrodes.