Nanodiamond Near Infrared Spectroscopy Sensor for Blood Analysis
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Solution Overview
Problem
Current methods are inadequate for accurately analyzing nitrogen monoxide concentrations in blood and blood gas noninvasively due to its small near infrared absorption peak, making it difficult to measure using conventional near infrared spectroscopy.
Innovation Solution
Incorporating nanodiamonds near the sample to amplify the near infrared absorption peak of nitrogen monoxide, allowing for precise measurement using near infrared spectroscopy, and utilizing a near infrared spectroscopy sensor with a nanodiamond layer to detect the compound in blood vessels.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If conventional near infrared spectroscopy is used to measure nitrogen monoxide, then the measurement can be performed noninvasively, but the measurement precision is insufficient due to the small absorption peak
Solution Approach 1:
Nanodiamond particles are introduced as an intermediary substance that interacts with nitrogen monoxide to amplify its near infrared absorption peak. The nanodiamond serves as a mediator between the measurement system and the target analyte, enhancing the detectable signal without requiring complex device modifications
Solution Approach 2:
The invention changes the physical parameter of the measurement system by introducing nanodiamond particles that alter the absorption characteristics of nitrogen monoxide. This parameter change amplifies the absorption peak intensity, making it detectable with conventional near infrared spectroscopy equipment
2Measurement precision
If nanodiamond is introduced to amplify the absorption peak, then the measurement precision improves, but the device complexity increases
Solution Approach 1:
The nanodiamond acts as a mediator that can be applied topically to the skin surface, simplifying the measurement setup by eliminating the need for complex invasive procedures or sophisticated signal amplification hardware
Solution Approach 2:
The nanodiamond particles create an enhanced optical signature that copies and amplifies the nitrogen monoxide absorption characteristics, making the weak signal detectable without requiring complex detection systems
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Enables accurate, noninvasive analysis of nitrogen monoxide concentrations in blood and blood gas by amplifying the near infrared absorption peak, overcoming the limitations of existing technologies.
Implementation Method 1
measuring a content of a compound having a near infrared absorption peak amplified by the nanodiamond in the sample using near infrared spectroscopy
Data Source
AI summary
An analysis method is provided which includes providing nanodiamond in a vicinity of a sample; and measuring a content of a compound having a near infrared absorption peak amplified by the nanodiamond in the sample using near infrared spectroscopy. Also, a near infrared spectroscopy sensor is provided which includes a near infrared spectroscopy sensor main body including a layer containing nanodiamond on a surface that receives near infrared rays of the near infrared spectroscopy sensor main body.