Nanoemulsion Oral Pouch for Consistent Bioavailability
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Solution Overview
Problem
Current smokeless tobacco products lack effective delivery systems for active ingredients that provide consistent bioavailability and sensory characteristics, with traditional formats often being granular or compressed, which may not optimize the absorption and experience of substances like nicotine or cannabinoids.
Innovation Solution
A pouched product containing a nanoemulsion composed of vegetable or mineral oil, water, an emulsifying agent, and an active ingredient, where the nanoemulsion is dispersed in or on a filler, with nanoparticles sized between 20 to 200 nm, and a zeta potential of -40 mV to 40 mV, enhancing bioavailability and sensory experience.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If traditional granular or compressed tobacco formats are used, then product structure is simple and manufacturing is easy, but bioavailability and absorption of active ingredients are inconsistent
Solution Approach 1:
The patent transforms the delivery system by changing the physical state and size parameters of active ingredients into nanoemulsion form (20-200 nm particles), which fundamentally alters absorption characteristics and achieves consistent bioavailability while maintaining a relatively simple pouch structure
Solution Approach 2:
The invention creates a composite delivery system combining nanoemulsion (oil phase with active ingredients), filler material, and binding agents into a unified pouchable composition that integrates multiple functional components into a single manufacturable product
2Manufacturing precision
If nanoemulsion is dispersed in filler, then bioavailability and sensory characteristics are improved, but manufacturing precision and formulation complexity increase
Solution Approach 1:
The patent applies preliminary action by pre-forming the nanoemulsion with controlled particle size (20-200 nm) and zeta potential (-40 to 40 mV) characteristics before incorporating it into the filler matrix, ensuring uniform dispersion and consistent performance while simplifying the overall manufacturing process
Solution Approach 2:
The invention implements local quality by optimizing specific parameters of the nanoemulsion (particle size distribution, zeta potential, oil-to-water ratio) to achieve desired dispersion uniformity and sensory characteristics in different regions of the pouchable composition
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The nanoemulsion-based pouched product improves the bioavailability and sensory characteristics of active ingredients, providing a discrete and aesthetically pleasing alternative to traditional smokeless tobacco products by ensuring consistent and efficient delivery through oral use.
Implementation Method 1
a nanoemulsion comprising a vegetable or mineral oil; water; from 0.01% to 15% by weight of an emulsifying agent; and an active ingredient
Implementation Method 2
the nanoemulsion comprising a vegetable or mineral oil; water; from 0.01% to 15% by weight of an emulsifying agent
Implementation Method 3
with nanoparticles sized between 20 to 200 nm, and a zeta potential of -40 mV to 40 mV
Data Source
Figure 1
AI summary
The disclosure provides a nanoemulsion including an oil, water, an emulsifying agent, and an active ingredient, flavorant, or a combination thereof. The nanoemulsion is intended for human oral use.