Nanoemulsion Composition for Stable Topical Delivery
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Solution Overview
Problem
Existing nanoemulsion-based topical compositions require high-pressure homogenization or sonication, limiting their stability and efficiency in delivering active agents dermally and transdermally, and often face issues with bioavailability, administration frequency, and flavor unpleasantness.
Innovation Solution
A stable oil-in-water nanoemulsion is produced through a simple process without high-pressure homogenization or sonication, using a combination of non-ionic emulsifying agents, amphoteric surfactants, emollients, humectants, and hydrating agents, along with active principles and optional oxygen-carrying agents, to achieve a narrow particle size distribution and efficient delivery.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Length of moving object
If high-pressure homogenization or sonication is used to produce nanoemulsion, then small oleous globule size is achieved, but device complexity and process complexity increase
Solution Approach 1:
The patent replaces mechanical homogenization systems (high-pressure homogenizers, sonicators) with a chemical self-assembly approach. The nanoemulsion is formed through spontaneous micellization of amphiphilic molecules in aqueous solution, eliminating the need for complex mechanical devices while achieving the desired nanoscale globule size through molecular self-organization rather than mechanical force.
Solution Approach 2:
The system utilizes the self-assembly property of amphiphilic molecules to form nanoemulsion structures automatically. The amphiphilic molecules spontaneously organize at the interface between oleous and aqueous phases, creating stable nanoemulsion without external mechanical intervention. This self-service mechanism eliminates the need for complex homogenization equipment.
2Ease of manufacture
If conventional emulsion methods are used, then ease of manufacture is maintained, but nanoemulsion stability and active agent delivery efficiency deteriorate
Solution Approach 1:
The patent changes the fundamental parameters of emulsion formation by using amphiphilic molecules with specific molecular structures (hydrophilic and hydrophobic segments) that enable spontaneous self-assembly. This chemical parameter change allows the system to achieve nanoemulsion stability through molecular self-organization rather than mechanical processing, maintaining manufacturing simplicity while improving stability.
Solution Approach 2:
The invention uses composite amphiphilic molecular structures that combine hydrophilic and hydrophobic characteristics. These composite molecules form stable interfaces between oil and water phases, creating nanoemulsions that are inherently more stable than conventional emulsions while being easier to manufacture through simple mixing processes.
3Ease of manufacture
If simple emulsion process is used, then ease of manufacture is improved, but particle size distribution homogeneity deteriorates
Solution Approach 1:
The patent replaces mechanical homogenization processes with chemical self-assembly mechanisms. The amphiphilic molecules spontaneously organize to form uniform nanoemulsion structures through molecular self-organization, achieving homogeneous particle size distribution without the need for complex mechanical processing that would compromise process simplicity.
Solution Approach 2:
The amphiphilic molecules act as intermediary agents that mediate between the oleous and aqueous phases. These intermediary molecules self-assemble to form stable interfaces, creating uniform nanoemulsion structures with narrow particle size distribution through chemical mechanisms rather than mechanical means, thus maintaining process simplicity while achieving manufacturing precision.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The solution results in excellent skin absorption, high bioavailability, reduced administration frequency, avoidance of first-pass metabolism, and improved patient adherence, with enhanced delivery of active agents without unpleasant flavors.
Implementation Method 1
the very small size of oleous globules is attained by at least one passage through a high-pressure homogenizer or sonicator
Implementation Method 2
Micro emulsions are aqueous dispersions of particles composed of a lipid nucleus surrounded by monolayers of surfactants and co-surfactants
Implementation Method 3
can be modulated to efficiently dispense one or more active principles incorporated in its nanoparticles, both dermally and transdermally
Data Source
AI summary
The present invention is directed to a suitable topical composition for cosmetic, pharmaceutical or dermatological use. In a particular aspect, it is a stable nanoemulsion whose particles have a narrow size distribution range. In another particular aspect, the invention is directed to an improved process for producing said composition.