Nanofiber Composite Membrane for Guided Bone Regeneration
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Solution Overview
Problem
Existing nanofiber membranes for guided bone regeneration face issues with brittleness during sterilization, leading to compromised physical properties, flexibility, and elasticity, as well as increased process costs and potential inflammatory reactions.
Innovation Solution
A nanofiber composite membrane is developed using a biocompatible plasticizer in the spinning solution, combined with electrospinning and thermal calendering, to maintain flexibility and elasticity while preventing brittleness during sterilization, and featuring a multi-layered structure with non-absorbent and absorbent layers for enhanced guided bone regeneration.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If nanofiber membranes are sterilized using conventional methods, then sterilization is achieved, but brittleness increases and physical properties deteriorate
Solution Approach 1:
The patent applies preliminary action by incorporating a plasticizer into the nanofiber membrane structure before sterilization. This pre-added component prepares the membrane to withstand the sterilization process without becoming brittle, thereby maintaining flexibility and elasticity after sterilization while still achieving effective sterilization.
Solution Approach 2:
The plasticizer acts as an intermediary substance that mediates between the sterilization process and the nanofiber membrane structure. It protects the membrane from the harmful effects of sterilization (brittleness) while allowing the sterilization to proceed effectively, thus resolving the contradiction between sterilization effectiveness and membrane strength.
2Reliability
If absorbent membrane materials are used for guided bone regeneration, then biocompatibility and safety improve, but space securing ability decreases
Solution Approach 1:
The patent employs composite materials by combining absorbent biodegradable polymers (for biocompatibility) with non-absorbent polymers or reinforcement structures (for space securing ability). This composite approach allows the membrane to simultaneously achieve excellent biocompatibility/safety characteristics while maintaining sufficient space securing ability for guided bone regeneration.
Solution Approach 2:
The patent applies local quality by creating a multi-layered or heterogeneous structure where different regions of the membrane have different properties. The absorbent biodegradable portions provide biocompatibility and safety, while non-absorbent or reinforced portions maintain space securing ability, allowing both contradictory requirements to be satisfied in different locations of the same membrane.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The membrane maintains physical properties and flexibility while preventing brittleness during sterilization, improving guided bone regeneration performance with a laminated structure that includes guided bone materials, reducing the need for secondary operations and minimizing inflammatory reactions.
Implementation Method 1
a nanofiber layer produced by an electrospinning method
Implementation Method 2
drying and thermal calendering the nanofiber web to sterilize the nanofiber web
Data Source
AI summary
Provided is a nanofiber composite membrane for guided bone regeneration, which includes: spinning a spinning solution by an electrospinning method to produce nanofibers; accumulating the nanofibers, to prepare a certain thickness of a nanofiber web; and drying and thermally calendering the nanofiber web to sterilize the nanofiber web, wherein the spinning solution contains a biocompatible plasticizer to maintain physical properties, flexibility and elasticity of the membrane, by suppressing an increase in brittleness in a sterilization treatment.