Nanofiber Skin Composition for Poorly Water-Soluble Actives
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Solution Overview
Problem
Existing methods for applying poorly water-soluble components to the skin are inefficient and do not maintain the amorphous state of these components, which affects their applicability and solubility.
Innovation Solution
A skin external composition comprising a polymer soluble in water and alcohol or ketone, combined with a poorly water-soluble component, is immobilized in a nanofiber deposit or crushed product, allowing the component to be dispersed in an aqueous medium in a liquid-liquid dispersion form, maintaining an amorphous state and enhancing solubility.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Quantity of substance
If poorly water-soluble components are applied directly to the skin, then the component concentration can be high, but the solubility and applicability are poor
Solution Approach 1:
A water-soluble polymer is used as an intermediary substance to solubilize the poorly water-soluble component. The polymer forms a complex with the active ingredient, enabling it to be dispersed in aqueous media while maintaining high concentration. This mediator approach resolves the contradiction by providing a bridge between the hydrophobic active ingredient and the hydrophilic application medium.
Solution Approach 2:
The solubility parameters of the poorly water-soluble component are modified through complexation with the water-soluble polymer. By changing the chemical environment and molecular interactions, the component achieves enhanced solubility in aqueous media while maintaining its high concentration, thus resolving the contradiction between concentration and solubility.
2Ease of operation
If nanofibers are used to support oil components, then the applicability to skin is improved, but the component may not maintain its amorphous state
Solution Approach 1:
A composite material system is formed by combining the water-soluble polymer with the poorly water-soluble component in specific ratios. This composite structure provides both the skin applicability of nanofibers and the stability to maintain the amorphous state of the active ingredient, resolving the contradiction between ease of application and compositional stability.
Solution Approach 2:
The local environment within the nanofiber structure is optimized to maintain the amorphous state of the poorly water-soluble component. By controlling the local composition, molecular interactions, and physical state within the fiber matrix, the system achieves both good skin applicability and stable amorphous state maintenance simultaneously.
3Reliability
If the component is dissolved in aqueous medium, then solubility is improved, but the concentration may be reduced due to saturation limits
Solution Approach 1:
The water-soluble polymer acts as a mediator that increases the apparent solubility of the poorly water-soluble component in aqueous media. By forming soluble complexes, the system can achieve higher component concentrations than would be possible through simple dissolution, resolving the contradiction between solubility improvement and concentration maintenance.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The composition efficiently applies a higher concentration of poorly water-soluble agents to the skin, maintaining their amorphous state for improved solubility and applicability, facilitating direct skin contact and supersaturated states.
Implementation Method 1
The component (b) is contained in an amorphous state in the fiber, and a particle size of the component (b) contained in the fiber is 0.1 nm or larger and 10 nm or smaller
Implementation Method 2
a method for applying a liquid composition to the skin, comprising the step of dissolving the assembly of fiber in an aqueous medium to obtain the liquid composition
Implementation Method 3
dispersed in a liquid comprising the component (C) as the main component. The liquid skin external composition is preferably a liquid skin external composition in a liquid-liquid dispersion form
Implementation Method 4
EP 2 589 693 A1 concerns a nanofiber made of a water-soluble polymer, having a cavity, and containing an oily component in the cavity
Data Source
Figure 1~2
Figure 3~4
AI summary
Provided is a liquid skin external composition which allows a poorly water-soluble component to be applied to a skin in a liquid state. An assembly of fiber for use in production of a liquid skin external composition, the assembly of fiber comprising (a) a polymer soluble in water and an alcohol or a ketone in a content of 50 mass% or more and 98 mass% or less with respect to the whole assembly of fiber and (b) a poorly water-soluble component in a content of 2 mass% or more and 40 mass% or less with respect to the whole assembly of fiber.