Nanoparticle Alteration and Physico-Chemical Disturbance for Compound Release
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Solution Overview
Problem
Nanoparticles administered to organisms often lose therapeutic properties when altered, such as being internalized in cells, leading to reduced efficacy in treatments like cancer or viral infections.
Innovation Solution
A method involving alteration and physico-chemical disturbance of nanoparticles to increase the release of bound compounds, which can enhance or maintain therapeutic activity by modifying properties like size, binding strength, and environment exposure.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If nanoparticles are internalized in cells or cellular compartments, then they can deliver compounds to targeted locations, but they lose therapeutic properties such as heating power and become inefficient for treatment
Solution Approach 1:
The patent divides the nanoparticle system into two functional components: a stable carrier nanoparticle that maintains structural integrity and a separate active compound (such as a photosensitizer or therapeutic agent) that can be released or activated upon reaching the target. This segmentation allows the carrier to protect the compound during transport while enabling controlled release at the destination, thus maintaining therapeutic efficacy without compromising nanoparticle stability.
Solution Approach 2:
The patent applies preliminary action by pre-loading the nanoparticle with the therapeutic compound and pre-positioning it for targeted delivery before administration. The nanoparticle is prepared in advance with the compound attached or encapsulated, and the system is designed to trigger release or activation only after reaching the target site (e.g., through pH changes, enzymatic activity, or external stimulation). This ensures the compound is delivered intact to the correct location before therapeutic action begins.
2Quantity of substance
If nanoparticles maintain strong binding of compounds, then they remain stable during transport, but the release of active compounds is insufficient for effective therapy
Solution Approach 1:
The patent employs dynamic binding mechanisms where the strength of compound-nanoparticle interaction changes in response to environmental conditions. The binding is strong under physiological conditions during transport but weakens or reverses when triggered by target-specific stimuli (such as pH drop in tumors, enzymatic activity, or light irradiation). This dynamic behavior enables stable transport followed by efficient compound release at the target site.
Solution Approach 2:
The patent utilizes parameter changes in the local environment (pH, temperature, redox potential, enzyme presence) to modulate the binding strength between the nanoparticle and the compound. The system is designed so that these parameter changes occur naturally at the target site, automatically triggering compound release without requiring additional energy input or complex control mechanisms. For example, a pH-sensitive linkage may remain intact at neutral pH during circulation but hydrolyze rapidly in the acidic tumor microenvironment.
3Adaptability or versatility
If nanoparticles are altered during internalization, then they can interact with cellular components, but they lose their heating power and therapeutic activity
Solution Approach 1:
The patent extracts the therapeutic function from the nanoparticle structure itself and places it in a separate, stable compound that the nanoparticle carries or protects. The nanoparticle serves purely as a delivery vehicle, while the active compound (such as a photosensitizer for photothermal therapy or a chemotherapeutic agent) retains its full therapeutic properties. This extraction ensures that alterations to the nanoparticle during cellular internalization do not compromise the therapeutic activity of the compound, as the compound's function is independent of the nanoparticle's structural integrity.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The method unexpectedly increases the release of active compounds from nanoparticles, enhancing their therapeutic effect by partial or complete release, particularly in targeted organs, thereby improving treatment outcomes for diseases like cancer or infections.
Implementation Method 1
They can then loose some of their properties such as their heating power
Implementation Method 2
breaking at least one bond between the altered compound and the altered nanoparticle
Implementation Method 3
said compounds being able to have a medical effect or to cure an animal or a human being by partial or complete release of these compounds, which preferentially located in or diffuse towards a targeted organ
Data Source
AI summary
A method for increasing the release of at least one compound, the compound being initially an initial compound bound to at least one initial nanoparticle, the initial compound bound to the initial nanoparticle forming an initial particle, wherein the initial particle includes at least one active ingredient, the method including at least one step of alteration of the initial particle and at least one step of physico-chemical disturbance of an altered particle resulting from the alteration.