Nanoparticle Coupled Plasmon Sensor for Low Concentration Protein Detection
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Conventional plasmon sensors have limitations in detecting protein biomarkers at low concentrations, requiring improvements in sensitivity for accurate diagnosis of diseases such as cancer, diabetes, and degenerative brain diseases.
Innovation Solution
A diagnosis method and kit utilizing a nanoparticle-nanopattern coupled system, where a first nanoparticle is printed on a substrate and a second nanoparticle is positioned adjacent to it, amplifying the plasmon phenomenon to enhance sensitivity, allowing for the detection of proteins at nanomole or picomole levels using gold, silver, or platinum nanostructures.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If a conventional plasmon sensor is used, then the device structure is simple, but the detection sensitivity is insufficient for low concentration proteins
Solution Approach 1:
The patent combines a first nanoparticle printed on a substrate with a second nanoparticle in close proximity to form a coupled nanoparticle system. This merging of two nanoparticles creates an enhanced plasmon phenomenon that significantly improves detection sensitivity for low concentration proteins, resolving the contradiction between simple structure and high sensitivity.
Solution Approach 2:
The patent employs a composite structure consisting of two different nanoparticles (first and second nanoparticles) with distinct properties. The first nanoparticle is printed on the substrate while the second nanoparticle is positioned adjacent to it, creating a composite plasmon system that achieves superior detection sensitivity compared to single nanoparticle systems.
2Quantity of substance
If the concentration of protein to be detected is reduced, then the diagnostic capability for early disease detection is improved, but the detection limit of conventional sensors is exceeded
Solution Approach 1:
By merging two nanoparticles into a coupled system, the patent amplifies the plasmon phenomenon, enabling detection of proteins at much lower concentrations (nanomole or picomole levels) while maintaining high measurement precision. This directly addresses the limitation of conventional sensors in detecting low concentration proteins.
Solution Approach 2:
The patent changes the physical parameters of the detection system by introducing a second nanoparticle with specific properties adjacent to the first nanoparticle. This parameter change in the sensor structure enables the system to detect proteins at lower concentrations with enhanced precision, overcoming the detection limits of conventional single-nanoparticle sensors.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The method and kit significantly enhance detection sensitivity, enabling the identification of proteins at much lower concentrations than conventional methods, facilitating early disease diagnosis and health condition monitoring.
Implementation Method 1
detecting a protein-based biomarker with higher sensitivity, based on a plasma sensor having a nanoparticle-nanopattern coupled to each other
Implementation Method 2
A localized surface plasmon resistance (LSPR) sensor refers to a sensing technique for measuring a fine change in refractive index, which results from a change in the surrounding environment of a metal nanostructure, through a change in absorbance
Data Source
AI summary
Disclosed is a method for diagnosing a target material by using a first substrate printed with a first nanoparticle. A second nanoparticle, which is bonded to a compound to be bound to the target material, is positioned at a distance adjacent to the first substrate.