Nanoparticle Detection System Using Collinear Multi-Wavelength Excitation
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Solution Overview
Problem
Conventional sample processing instruments are not well-suited for detecting very small nanoparticles, such as biological or non-biological nanoparticles, due to insufficient sensitivity to detect or discern optical signals from these particles, resulting in inaccurate detection results.
Innovation Solution
A detection system for nanoparticles is provided, comprising a light emitting unit and a light collection unit. The light emitting unit includes multiple light sources with different wavelengths, focused through a focusing lens and adjustable dichroic mirrors to ensure collinear beams, while the light collection unit includes a side collection part with optical focusing lenses, collection fibers, and wavelength division multiplexers to analyze the collected light beams.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional detection systems with multiple light sources focusing on different detection positions are used, then crosstalk can be prevented or reduced, but detection sensitivity for very small nanoparticles is insufficient
Solution Approach 1:
The patent merges multiple light sources (multiple wavelengths) into a single detection position by using a focusing lens to focus light beams from different light sources onto the same spot. This allows simultaneous multi-wavelength excitation of nanoparticles at one location, improving detection sensitivity while maintaining crosstalk prevention through proper optical design
Solution Approach 2:
The patent introduces a focusing lens as an intermediary optical element between the multiple light sources and the detection position. This focusing lens enables precise convergence of light beams from different sources onto the same detection point, thereby enhancing the optical signal from nanoparticles without causing crosstalk
2Productivity
If conventional sample processing instruments are used for large particles, then high flow rates can be maintained, but detection sensitivity for nanoparticles is insufficient
Solution Approach 1:
The patent changes the optical parameters by using multiple light sources with different wavelengths focused onto a single detection position. This parameter change in the optical configuration enables enhanced sensitivity for detecting small nanoparticles while maintaining efficient sample processing capabilities
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The detection system achieves high precision in detecting nanoparticles by enhancing the sensitivity to optical signals from nanoparticles, allowing for accurate analysis and improved detection efficiency, particularly for particles ranging from 40 nanometers to 1000 nanometers.
Implementation Method 1
The light emitting unit includes multiple light sources and a focusing lens, and the light beams emitted by the multiple light sources are focused through the focusing lens on a same detection position
Implementation Method 2
the light beams emitted by the multiple light sources have wavelengths different from each other, and a dichroic mirror is provided between each light source and the focusing lens. Dichroic mirrors can combine beams of different wavelengths
Implementation Method 3
The light collection unit is configured to collect light beams from the nanoparticle so as to analyze the nanoparticles according to the collected light beams
Implementation Method 4
The optical focusing lens group includes a concave mirror and an aspheric lens and is configured to focus a light beam emitted from the nanoparticle. The optical focusing lens group focuses the light beam into the collection fiber
Data Source
AI summary
A detection system and a sample processing instrument for nanoparticles are provided. The detection system includes a light emitting unit and a light collection unit. The light emitting unit is configured to emit a light beam and project the light beam onto a nanoparticle to be detected. The light collection unit is configured to collect light beams from the nanoparticle so as to analyze the nanoparticles according to the collected light beams. The light emitting unit includes multiple light sources and a focusing lens, and the light beams emitted by the multiple light sources are focused through the focusing lens on a same detection position through which the nanoparticle is to pass.