Nanoparticle Drug Delivery for Targeted Bioavailability
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Solution Overview
Problem
Existing methods for delivering health and longevity enhancing therapies are inefficient and often result in undesired side effects due to the lack of targeted and controlled delivery of anabolic hormones and other therapeutic agents.
Innovation Solution
A system and method that combines a non-toxic therapeutic anabolic hormone replenishment with rapamycin and cannabidiol, utilizing a cannabinoid substance like CBD to improve bioavailability and target delivery to specific sites in the body, such as the intestinal mucosa, for enhanced absorption and reduced systemic toxicity.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If anabolic hormones and therapeutic agents are delivered through conventional methods, then therapeutic effects are achieved, but side effects increase and delivery efficiency decreases
Solution Approach 1:
The patent segments the delivery system by using distinct nanoparticle carriers for different therapeutic agents (anabolic hormones, rapamycin, cannabinoids). Each nanoparticle type can be optimized independently for its specific drug payload, enabling targeted delivery to different tissues while minimizing off-target side effects.
Solution Approach 2:
The patent implements local quality by designing nanoparticles with surface modifications and ligand conjugation that enable tissue-specific targeting. Different nanoparticles can be directed to different organs or cell types, delivering therapeutic agents locally where needed rather than systemically, thereby reducing side effects.
2Quantity of substance
If therapeutic agents are delivered systemically, then broad coverage is achieved, but bioavailability decreases and toxicity increases
Solution Approach 1:
The patent uses nanoparticles as intermediary carriers that protect therapeutic agents from degradation in the bloodstream while facilitating their transport to target tissues. The nanoparticle shell acts as a mediator that shields hydrophobic drugs from aqueous environments and enables controlled release at the target site.
Solution Approach 2:
The patent employs parameter changes by modifying nanoparticle properties such as surface charge, hydrophobicity, and ligand attachment to optimize circulation time, tissue penetration, and cellular uptake. These parameter adjustments enhance bioavailability while maintaining broad therapeutic coverage.
3Reliability
If high doses of therapeutic agents are administered, then therapeutic efficacy is improved, but toxicity and side effects increase
Solution Approach 1:
The patent segments the dosing strategy by delivering different therapeutic agents in controlled ratios through separate nanoparticle formulations. This enables optimization of each agent's dose independently, achieving synergistic effects at lower overall doses and reducing toxicity.
Solution Approach 2:
The patent applies partial action by using sub-threshold doses of individual agents that, when combined in specific ratios within nanoparticles, produce therapeutic effects greater than the sum of individual components, thereby reducing the need for high doses of any single agent.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This approach enables more predictable and targeted delivery of therapeutic agents, improving quality of life and healthy lifespan by minimizing side effects and maximizing the benefits of the combined compounds.
Implementation Method 1
Biodelivery/availability of the rapamycin and prohormone is improved using a cannabinoid substance, preferably CBD or a derivative to target delivery to intestinal mucosa and/or improve buccal uptake
Data Source
AI summary
The present invention discloses a system and method for preparing and delivering various health and longevity compositions. This invention is designed to improve the quality of life and lifespan of mammals. The compositions of the present invention are selected and designed for the purpose of efficiently delivering health and longevity enhancing therapies through oral supplementation; misting; nasal spray; intravenous, IM, and/or sub-cutaneous, injection; suppository; etc. A non-toxic therapeutic anabolic hormone replenishment is combined with rapamycin and cannabidiol. The three compounds work together to improve quality of life and healthy lifespan. Preferred additional included supplements may include metformin, growth hormone, and/or supplemented minerals. A preferred embodiment features low dose continuous supplementation, e.g., to be incorporated with a daily meal. The process of the present invention delivers an orally ingested substance, e.g., a snack, a human food supplement, an animal treat, etc., that contains the active compounds to be absorbed by the digestive system or delivered into the bloodstream.