Nanoparticle Formulations for Dermal Delivery With Reduced Side Effects

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Solution Overview

Problem

There is a need for improved nanoparticle compositions for topical and non-topical administration to effectively treat a wide spectrum of disorders, particularly those associated with the skin, and for compositions that can deliver therapeutic agents efficiently and specifically to biologically relevant target sites with minimal side effects.

Innovation Solution

Nanoparticle compositions comprising an oil, aqueous dispersion medium, surfactant, and optionally a biologically active agent, formulated for various routes of administration, including topical and transdermal delivery, using specific ingredients such as 1349 oil, polysorbate 80, and isotonic sodium chloride solution, with cream and lotion formulations enhancing delivery efficacy.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If nanoparticle compositions are formulated for topical administration to treat skin disorders, then therapeutic effectiveness at target sites is improved, but achieving efficient and specific delivery with minimal side effects remains challenging

Engineering Contradiction:

Improvetherapeutic effectivenessVSAvoidside effects

Core Design Contradiction:

ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The composition is segmented into distinct functional components: oil phase (1349 oil) for therapeutic agent solubility, aqueous phase for dispersion, surfactant (polysorbate 80) for stabilization, and preservatives (parabens) for contamination prevention. This segmentation allows each component to perform its specific function optimally while working together to achieve targeted delivery with reduced side effects.

Inventive Principle:

Principle #1Segmentation

Solution Approach 2:

The surfactant polysorbate 80 acts as an intermediary between the oil phase and aqueous phase, enabling stable emulsion formation and facilitating controlled release of therapeutic agents. This intermediary component resolves the contradiction by mediating the interaction between hydrophobic therapeutic agents and the aqueous delivery system, improving delivery efficiency while maintaining safety.

Inventive Principle:

Principle #24Intermediary (Mediator)

2Productivity

If nanoparticle compositions use multiple ingredients for enhanced delivery efficacy, then therapeutic delivery to target sites is improved, but composition complexity increases

Engineering Contradiction:

Improvedelivery efficacyVSAvoidcomposition complexity

Core Design Contradiction:

ProductivityVSDevice complexity

Solution Approach 1:

Each ingredient in the composition serves multiple functions: 1349 oil provides both therapeutic agent solubility and emulsion stability; polysorbate 80 acts as surfactant and emulsifier; parabens provide preservative function while maintaining compatibility with other components. This multi-functionality reduces overall composition complexity while maintaining high delivery efficacy.

Inventive Principle:

Principle #6Universality (Multi-functionality)

Solution Approach 2:

The composition utilizes specific concentration ranges and physical-chemical parameters (oil-to-aqueous phase ratio, surfactant concentration, pH buffer conditions) to optimize delivery efficacy. By carefully controlling these parameters within defined ranges, the composition achieves high productivity without excessive complexity.

Inventive Principle:

Principle #35Parameter changes

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The compositions achieve controlled and efficient delivery of therapeutic agents to target sites like the dermis with reduced side effects, providing therapeutic benefits without significant systemic impact.

Implementation Method 1

nanoparticle compositions comprise an oil, and aqueous dispersion medium, a surfactant

Methodology Applied

Scientific EffectSurfactant: Surfactant

Implementation Method 2

formulated for various routes of administration, including topical and transdermal delivery

Methodology Applied

Scientific EffectTransdermal delivery: Permeation

Data Source

PatentUS20250241848A1Nanoparticle compositions, formulations thereof, and uses therefor

Publication Date: 2025.07.31 ANTERIOS INC

AI summary

The present invention describes novel nanoparticle compositions, and systems and methods utilizing them for treating disorders and/or conditions. Methods generally involve administering nanoparticle compositions (e.g., nanoparticle compositions comprising at least one known therapeutic agent and/or independently active biologically active agent; and/or empty nanoparticle compositions) to a subject in need thereof.