Nanoparticle Complex with Lipid Tube Structure for Tumor Penetration

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Solution Overview

Problem

Conventional methods for improving cellular uptake of nanoparticles for drug delivery suffer from instability and poor biocompatibility, leading to inadequate efficacy in reaching spheroid-type tumor cells.

Innovation Solution

A nanoparticle complex is developed using a top-down process where a lipid structure with a tube shape is bonded to the surface of nanoparticles, enhancing cellular uptake through endocytosis and tissue penetration, utilizing a lipid-based material with high stability and biocompatibility, and mechanical force is applied to form the lipid structure on the nanoparticle surface.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If conventional methods are used to improve cellular uptake of nanoparticles, then cellular uptake is enhanced, but stability and biocompatibility deteriorate

Engineering Contradiction:

Improvecellular uptakeVSAvoidstability

Core Design Contradiction:

ReliabilityVSStability of the object's composition

Solution Approach 1:

The patent applies composite materials by combining nanoparticles with lipid structures to form a nanoparticle complex. The lipid structure comprises a lipid bilayer membrane and a peptide, creating a composite structure that enhances cellular uptake while maintaining stability and biocompatibility. This composite approach allows the system to leverage the advantages of both nanoparticle carriers and lipid-based cellular membranes.

Inventive Principle:

Principle #40Composite materials

2Reliability

If conventional methods are used to improve cellular uptake of nanoparticles, then cellular uptake is enhanced, but biocompatibility deteriorates

Engineering Contradiction:

Improvecellular uptakeVSAvoidbiocompatibility

Core Design Contradiction:

ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The nanoparticle complex uses a composite structure where the lipid bilayer membrane and peptide combination mimics natural cellular structures, thereby improving biocompatibility. The lipid-based structure is recognized by cellular membranes, reducing immune recognition and enhancing biocompatibility while maintaining improved cellular uptake.

Inventive Principle:

Principle #40Composite materials

3Productivity

If a top-down process is used to manufacture nanoparticle complex, then mass production is enabled, but manufacturing precision may be compromised

Engineering Contradiction:

Improvemass production capabilityVSAvoidsurface modification precision

Core Design Contradiction:

ProductivityVSManufacturing precision

Solution Approach 1:

The top-down manufacturing process employs preliminary action by pre-forming lipid structures (lipid bilayer membranes with peptides) before assembling them with nanoparticles. This approach allows for standardized preparation of lipid components, enabling mass production while maintaining consistent structural characteristics and surface modification quality across large batches.

Inventive Principle:

Principle #10Preliminary action

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The nanoparticle complex effectively penetrates cell membranes and spheroid-type tumor cells, demonstrating improved cellular uptake and drug delivery efficiency, while allowing for mass production.

Implementation Method 1

the nanoparticle complex undergoes endocytosis, directly penetrates a cell membrane

Methodology Applied

Scientific EffectEndocytosis:

Implementation Method 2

mechanical force is applied thereto to thus crush the lipidomes, so that the lipid structure is formed on the surface of the nanoparticle

Methodology Applied

Scientific EffectMechanical force: Mechanical Force

Data Source

PatentUS11865211B2Nanoparticle complex showing improved cellular uptake through surface modification using lipid and manufacturing method therefor

Publication Date: 2024.01.09 INSBIOPHARM CO LTD

AI summary

The present disclosure relates to a nanoparticle complex that is taken into cells to be used for the treatment of diseases, and a method of manufacturing the same using a top-down process. In the top-down process, surfaces of nanoparticles are modified with a lipid-based material having high stability and excellent biocompatibility, thereby improving endocytosis efficiency. A lipid structure having a tube shape is bonded to a portion of the surface of the nanoparticle, so that the nanoparticle complex undergoes endocytosis, directly penetrates a cell membrane, and is effectively taken into spheroid-type tumor cells. The lipid structure is not directly attached to the nanoparticles, lipid-based lipidomes (such as bubbles and liposomes) are bonded to the nanoparticles, and mechanical force is applied thereto to thus crush the lipidomes, so that the lipid structure is formed on the surface of the nanoparticle.