Nanosecond Millisecond Pulse Control for Ablation
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Existing electroablation methods have limited ablation range, poor ablation effect, and are prone to muscle contractions, requiring anesthetics, which increases treatment costs and side effects.
Innovation Solution
A pulse control method and apparatus that generate a high-voltage nanosecond pulse sequence and a low-voltage millisecond pulse sequence, where the nanosecond pulse causes irreversible electroporation close to the electrode and reversible electroporation further away, while the millisecond pulse conducts electrolysis to induce apoptosis, reducing muscle contractions and improving treatment efficacy.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Device complexity
If a single pulse sequence is used for electroablation, then the device structure is simple, but the ablation range is limited and ablation effect is poor
Solution Approach 1:
The patent divides the pulse sequence into two distinct segments: nanosecond pulse sequence for irreversible electroporation near the electrode and millisecond pulse sequence for reversible electroporation further away. This segmentation allows each pulse type to optimize its specific function, thereby expanding the ablation range and improving ablation effect without excessive device complexity
Solution Approach 2:
The patent combines nanosecond pulse sequence and millisecond pulse sequence into a unified electroablation system. By merging these two pulse types with different characteristics, the system achieves both local precise ablation and broader tissue treatment, significantly improving overall ablation range and effect
2Productivity
If high-voltage pulse sequence is used to increase ablation range, then ablation effect improves, but muscle contraction occurs frequently
Solution Approach 1:
The patent applies different pulse characteristics to different regions: high-voltage nanosecond pulses for local irreversible electroporation near the electrode, and low-voltage millisecond pulses for broader reversible electroporation. This local quality differentiation achieves effective ablation while minimizing muscle contraction by using appropriate voltage levels for each region
Solution Approach 2:
The patent changes pulse parameters (voltage, pulse width, frequency) between nanosecond and millisecond sequences. By adjusting these parameters, the system achieves effective ablation at close distances while using lower voltages at greater distances to avoid muscle contraction, thus expanding ablation range without excessive harmful effects
3Productivity
If high-voltage pulse sequence is used to achieve thorough ablation, then ablation effect improves, but anesthetic is required increasing treatment cost
Solution Approach 1:
The patent segments the ablation process into two stages using different pulse sequences, allowing thorough ablation to be achieved through coordinated action of nanosecond and millisecond pulses rather than requiring continuously high voltage, thereby reducing or eliminating the need for anesthetics and lowering treatment costs
Solution Approach 2:
The patent employs periodic alternation between nanosecond and millisecond pulse sequences. This periodic action enables thorough ablation through repeated cycles of irreversible and reversible electroporation, achieving effective treatment without requiring anesthetics, thus reducing treatment costs
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The method achieves a larger and more thorough ablation range with reduced muscle contractions and anesthetic use, improving patient experience and reducing treatment costs and side effects.
Implementation Method 1
electric-field pulses are transmitted to lesion cells, such that ions inside and outside the cells move and are gathered on both sides of the outer cell membranes, causing a drastic change in a transmembrane potential and the occurrence of electroporation in the outer cell membrane
Implementation Method 2
The low-voltage millisecond pulse sequence can conduct electrolysis of the cells relatively far from the electrode needle in which reversible electroporation occurs
Data Source
AI summary
A pulse control method and apparatus, an ablation device (110) and system (100), and a storage medium. The pulse control method comprises: controlling a pulse generator (112) to output a nanosecond pulse sequence and a millisecond pulse sequence, the amplitude of the nanosecond pulse sequence being greater than a preset first threshold voltage, and the amplitude of the millisecond pulse sequence being less than a preset second threshold voltage. The nanosecond pulse sequence having the amplitude greater than the threshold voltage cooperates with the millisecond pulse sequence having the amplitude less than the threshold voltage, such that the effective ablation range can be enlarged, the ablation is more thorough, the muscle contraction amplitude can be effectively reduced, or the muscle contraction probability is reduced, the treatment experience feeling of a patient can be improved, and the use of anesthetics can be reduced or even not needed.