Nanosensor Platform for Simultaneous Disease Detection
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Solution Overview
Problem
Current methods for rapid and accurate detection of diseases and pathogens are costly and inefficient, particularly in volume production processes, due to challenges in deposition and curing of nanosensor materials.
Innovation Solution
The development of nanosensor platform devices and processes that utilize direct deposition or transfer methods for nanosensor materials, combined with thermal or radiative curing, to enable cost-effective and rapid detection of multiple diseases or pathogens simultaneously using impedimetric biosensors.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of manufacture
If traditional deposition and curing methods are used for nanosensor materials in volume production, then manufacturing processes can be established, but the process becomes costly and inefficient
Solution Approach 1:
The patent applies preliminary action by pre-functionalizing nanosensor materials with specific biomolecular recognition elements (antibodies, aptamers, or peptides) before deposition. This pre-preparation step enables direct deposition onto sensor substrates without requiring subsequent complex curing or functionalization steps during production, thereby reducing manufacturing costs and improving efficiency in volume production while maintaining high detection accuracy for multiple pathogens simultaneously
2Measurement precision
If multiple nanosensor materials are deposited and cured for simultaneous disease detection, then detection accuracy improves, but manufacturing complexity increases
Solution Approach 1:
The patent applies segmentation by dividing the simultaneous detection of multiple diseases into separate functional zones on a single sensor substrate. Each zone contains specifically functionalized nanosensor materials targeting different pathogens (viruses, bacteria, or their biomarkers). This segmentation allows accurate simultaneous detection of multiple analytes while simplifying manufacturing, as each zone can be independently prepared and deposited using straightforward techniques without requiring complex multi-layer curing processes
Solution Approach 2:
The patent applies universality by developing a single multifunctional sensor substrate that can detect multiple types of pathogens (viruses, bacteria, and their biomarkers) simultaneously through direct deposition of pre-functionalized nanosensor materials. This universal platform eliminates the need for separate specialized sensors for each pathogen type, thereby maintaining high detection accuracy across multiple targets while significantly reducing manufacturing complexity compared to producing individual specialized sensors
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This approach allows for personalized, early diagnosis of diseases, real-time analysis of infectious outbreaks, and efficient healthcare resource allocation, while reducing production costs and improving detection accuracy.
Implementation Method 1
deposition methods or transfer methods of nanosensor materials
Implementation Method 2
drying, curing and preparing those materials
Data Source
AI summary
The embodiments disclose a method including providing impedimetric biosensor electrodes and circuits on a substrate, providing at least two different biopolymer materials on the conductive impedimetric biosensors electrodes and circuits, applying a predetermined electrical current to the impedimetric biosensor electrodes for establishing a baseline value, providing at least one biologic sample onto the impedimetric biosensors electrodes for detection of at least one disease microorganism, measuring the electrical current after contact with the at least one biologic sample for changes in the baseline value, recording changes in the electrical current measurements, analyzing the electrical current measurements for identifying predetermined detected disease microorganisms electrical current measurements changes, and determining the concentration of a detected disease microorganism.