Nanostructured Intraocular Lens Surface for After Cataract Control
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Solution Overview
Problem
Intraocular lenses often experience relapse of opacity due to cell proliferation and migration, leading to after cataract, as existing surgical methods fail to effectively inhibit these processes.
Innovation Solution
An intraocular lens with a pattern of ridges and grooves having nanostructure surface roughness is developed, where the grooves have an average roughness of less than 200 nm, and the ridges and grooves have varying widths, forming a boundary portion to guide cell migration and inhibit cell proliferation.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional intraocular lens without pattern is used, then surgical operation is simple, but cell proliferation and migration occur leading to after cataract
Solution Approach 1:
The lens surface is segmented into ridges and grooves with specific width ratios (1:2 to 1:8), creating distinct regions that guide cell migration along the grooves while preventing random proliferation, thus resolving the contradiction between maintaining simple structure and preventing after cataract
Solution Approach 2:
Different regions of the lens surface are given different properties: grooves with nanostructure roughness (Ra < 200 nm) for guiding cell migration, and ridges for providing structural support and additional guidance, allowing the lens to prevent after cataract while maintaining overall structural simplicity
2Reliability
If lens pattern is designed to inhibit cell migration, then after cataract is prevented, but cell migration control mechanism becomes complex
Solution Approach 1:
The groove width is specifically designed to be 10 μm and ridge width 5 μm with a ratio of 1:2 to 1:8, and the groove surface roughness is controlled to Ra < 200 nm. These parameter changes create a passive guidance system that controls cell migration through physical geometry rather than complex active mechanisms, achieving reliable cell migration control without excessive design complexity
Solution Approach 2:
The invention introduces nanostructure roughness (nanometer scale) on the groove surfaces, adding a dimensional aspect that influences cell behavior at the cellular level. This nanoscale dimension provides enhanced cell migration guidance without requiring complex macroscopic structures, resolving the contradiction between effective cell control and design simplicity
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The nanostructured pattern effectively delays or inhibits cell migration, preventing the recurrence of opacity and promoting cell migration in a controlled direction, thereby reducing the risk of after cataract.
Implementation Method 1
each of the grooves has a nanostructure roughness. The surface of the groove may have an average roughness Ra less than 200 nm
Implementation Method 2
processing a predetermined pattern for guiding cells by performing laser irradiation on the haptic portion and the optic portion
Data Source
AI summary
Provided is an intraocular lens including: an optic portion; and a haptic portion extending from the optic portion, wherein a pattern having ridges and grooves is formed on at least one of the optic portion and the haptic portion, and each of the grooves has a nanostructure roughness. Provided also is a method of manufacturing an intraocular lens, the method including: seating an object to be processed including an optic portion and at least one haptic portion extending from the optic portion, processing a predetermined pattern for guiding cells by performing laser irradiation on the haptic portion and the optic portion, forming grooves having a nanostructure surface roughness in the predetermined pattern formed by laser beams, and the surface of each of the grooves has an average roughness Ra less than 200 nm.