NARH and NR Combination for Intracellular NAD+ Biosynthesis

Resolve Bottlenecks,
Find Innovative SolutionsGenerate Solutions

Solution Overview

Problem

Current methods fail to effectively increase intracellular NAD+ levels in cells, which is crucial for improving cell and tissue health, energy metabolism, and addressing metabolic and mitochondrial-related diseases.

Innovation Solution

A composition comprising a combination of NARH and NR is administered orally to enhance NAD+ biosynthesis in cells, particularly in tissues like the liver, kidney, and skeletal muscle, thereby increasing mitochondrial energy and preventing fatigue.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Quantity of substance

If conventional single-precursor methods are used to increase NAD+ levels, then the approach is simple, but the effectiveness is insufficient

Engineering Contradiction:

Improveintracellular NAD+ levelsVSAvoideffectiveness of NAD+ biosynthesis

Core Design Contradiction:

Quantity of substanceVSProductivity

Solution Approach 1:

The patent combines two NAD+ precursors (NARH and NR) into a single composition that works synergistically to increase intracellular NAD+ levels more effectively than either precursor alone. This merging of complementary precursors resolves the contradiction by achieving higher NAD+ accumulation through combined biosynthetic pathways.

Inventive Principle:

Principle #5Merging (Combining)

Solution Approach 2:

The invention uses a composite approach by formulating a composition containing both NARH and NR precursors, creating a synergistic effect that enhances NAD+ production capacity. This composite material strategy allows the system to overcome the limitations of single-precursor methods and achieve more effective NAD+ biosynthesis.

Inventive Principle:

Principle #40Composite materials

2Reliability

If NAD+ levels are increased to improve cell health and energy metabolism, then therapeutic benefits are achieved, but the complexity of achieving effective biosynthesis increases

Engineering Contradiction:

Improvecell and tissue healthVSAvoidNAD+ biosynthesis pathway

Core Design Contradiction:

ReliabilityVSDevice complexity

Solution Approach 1:

The patent employs NARH and NR as intermediary substances that facilitate NAD+ biosynthesis. These precursors act as mediators that convert into NAD+ through enzymatic reactions, simplifying the overall process by providing readily available building blocks that enhance cellular energy metabolism and health without requiring complex de novo synthesis pathways.

Inventive Principle:

Principle #24Intermediary (Mediator)

3Ease of operation

If oral administration of NAD+ precursors is used, then ease of administration is improved, but bioavailability and intracellular accumulation are limited

Engineering Contradiction:

Improveoral administrationVSAvoidintracellular NAD+ accumulation

Core Design Contradiction:

Ease of operationVSQuantity of substance

Solution Approach 1:

The patent optimizes parameters of the NAD+ precursor composition, specifically using the combination of NARH and NR in particular ratios and concentrations. This parameter optimization enhances bioavailability upon oral administration, allowing sufficient intracellular accumulation to achieve therapeutic effects while maintaining ease of oral delivery.

Inventive Principle:

Principle #35Parameter changes

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The combination of NARH and NR synergistically increases NAD+ levels, improving cellular energy, preventing metabolic and muscle fatigue, and treating or preventing mitochondrial-related diseases, while also promoting immune function and overall health.

Implementation Method 1

The combination of NARH and NR synergistically increases NAD+ levels

Methodology Applied

Scientific EffectSynergistic biosynthesis:

Implementation Method 2

increase NAD+ biosynthesis in one or more cells of the individual

Methodology Applied

Scientific EffectNAD+ biosynthesis:

Data Source

PatentUS20240245714A1Composition and methods using combination of NARH and NR to produce intracellular nicotinamide adenine dinucleotide (NAD+)

Publication Date: 2024.07.25 SOCIETE DES PRODUITS NESTLE SA

AI summary

Compositions and methods that use a combination of NARH and NR to produce intracellular NAD+/NADH. The compositions can be used in food or beverage applications, pharmaceutical formulations, or as a dietary supplement. The compositions can be administered to an individual to promote the increase of intracellular levels of nicotinamide adenine dinucleotide (“NAD+”) in cells and tissues for improving cell and tissue survival or overall cell and tissue health. Also, the compositions can be administered to an individual to treat or prevent a mitochondria-related disease or a condition associated with altered mitochondrial function in an individual in need thereof or at risk thereof. The mitochondria-related disease or condition is selected from the group consisting of deleterious effects of aging, stress (e.g., oxidative stress), obesity, overweight, reduced metabolic rate, metabolic syndrome, diabetes mellitus, complications from diabetes, hyperlipidemia, neurodegenerative disease, cognitive disorder, stress-induced or stress-related cognitive dysfunction, mood disorder, anxiety disorder, age-related neuronal death or dysfunction, chronic kidney disease, kidney failure, trauma, infection, cancer, hearing loss, macular degeneration, myopathies and dystrophies, and combinations thereof.