Nasal Cannabidiol Gel for Bypassing First-Pass Metabolism
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Solution Overview
Problem
Current administration methods for cannabinoids, such as THC and CBD, suffer from low bioavailability, hepatic first-pass metabolism, irritation, and lack of selective targeting of disease sites, particularly in treating conditions like schizophrenia and epilepsy.
Innovation Solution
Development of nasal pharmaceutical compositions in the form of semi-solid or viscous liquids, specifically designed for intranasal application, allowing direct deposition in the nasal vestibule to bypass hepatic metabolism and enhance systemic and brain delivery of cannabinoids.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If cannabinoids are administered through current methods (oral, inhalation), then they can reach the systemic circulation, but they suffer from low bioavailability and hepatic first-pass metabolism
Solution Approach 1:
The invention segments the absorption pathway by utilizing the nasal cavity's highly vascularized mucosal membrane as a separate absorption route that bypasses the gastrointestinal tract and liver metabolism, directly entering systemic circulation through nasal blood vessels
Solution Approach 2:
The invention uses a specialized nasal gel formulation containing penetration enhancers and surfactants as intermediaries to facilitate cannabinoid penetration through the nasal mucosal barrier, enabling efficient absorption without hepatic first-pass metabolism
2Ease of operation
If cannabinoids are administered through current methods, then they can be delivered systemically, but they cause irritation and lack selective targeting of disease sites
Solution Approach 1:
The invention applies local quality by formulating cannabinoids in a nasal gel that can be precisely deposited onto specific regions of the nasal mucosa, allowing selective targeting of disease sites while the gel base provides localized soothing effects that reduce irritation
Solution Approach 2:
The nasal gel formulation acts as an intermediary carrier that protects the cannabinoid molecules from directly irritating the nasal mucosa, while the gel matrix and incorporated soothing agents mitigate irritation and enable controlled, targeted delivery to specific disease sites
3Duration of action of moving object
If nasal gel formulations are used, then rapid and sustained delivery is achieved, but the formulation complexity increases
Solution Approach 1:
The invention utilizes parameter changes by adjusting the gel's viscosity, rheology, and phase transition properties to achieve thixotropic behavior that provides sustained release of cannabinoids over time while maintaining ease of application through controlled flow characteristics
Solution Approach 2:
The invention employs composite materials by combining cannabinoids with a multi-component gel base containing gelling agents, penetration enhancers, surfactants, and soothing agents, creating a complex formulation that achieves sustained delivery through the synergistic interaction of its components
Data Source
AI summary
A nasally administered cannabinoid semi-solid or viscous liquid composition; nasal methods for administering the nasal pharmaceutical compositions; methods for manufacturing the nasal pharmaceutical compositions; and nasal methods of treating diseases treatable by the nasal pharmaceutical compositions formulated with a cannabinoid or mixtures thereof.