Liquid-Powder Nasal Composition for Longer Mucosal Contact
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Solution Overview
Problem
Nasal compositions in liquid form often flow out of the nasal cavity due to gravity and nasal clearance before being absorbed, reducing the efficacy of therapeutic agents.
Innovation Solution
A combination of a liquid and powder nasal composition, where the powder enhances the mucoadhesive properties of the liquid, prolonging its contact time with the nasal mucosa and increasing the absorption of therapeutic agents.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If a liquid nasal composition is applied, then the therapeutic agent can be delivered to the nasal cavity, but the liquid flows out due to gravity and nasal clearance before absorption, reducing efficacy
Solution Approach 1:
The invention combines a liquid nasal composition containing therapeutic agents with a powder composition containing mucoadhesive polymers. When applied together, these materials form a composite formulation that adheres to the nasal mucosa, preventing premature clearance by gravity and nasal secretions. This composite approach allows the liquid therapeutic to remain in contact with the absorption site long enough to be effective.
Solution Approach 2:
The powder composition acts as an intermediary carrier that mediates between the liquid therapeutic agent and the nasal mucosa. The mucoadhesive polymer in the powder forms a matrix or gel that traps the liquid therapeutic and anchors it to the mucosal surface, serving as a bridge that prevents the liquid from flowing away while maintaining therapeutic contact.
2Reliability
If a mucoadhesive pharmaceutical solution is used, then the contact time and efficacy are improved, but the development cost and time increase due to fixed formulation requirements
Solution Approach 1:
The invention segments the nasal composition into two separate components: a liquid composition containing the therapeutic agent(s) and a powder composition containing the mucoadhesive polymer. This segmentation allows each component to be manufactured and formulated independently using existing, well-established formulations, avoiding the need to develop and approve a completely new fixed combination formulation while still achieving the benefits of mucoadhesion.
Solution Approach 2:
The powder composition containing mucoadhesive polymer serves multiple functions: it acts as an adhesive to retain the liquid therapeutic, provides a carrier matrix for drug delivery, and can potentially include additional therapeutic agents. This multi-functionality reduces the need for separate development of multiple components, simplifying the manufacturing and regulatory approval process.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The powder composition prolongs the liquid's contact time, enhancing the efficacy of therapeutic agents by increasing their absorption and maintaining their effects for a longer duration.
Implementation Method 1
the second powder composition part slowing down the clearance of the first liquid composition part due to the creation of weak and/or temporary bonds between one or more components of the first and second composition parts and/or between one or more components of the first and second composition parts and the nasal mucosa
Implementation Method 2
A drug molecule can be transferred quickly from the nasal cavity across a single epithelial layer of the mucosa and directly into the systemic blood circulation of the patient
Data Source
AI summary
A nasal composition is provided comprising or consisting of a first composition part in the form of a liquid for nasal application to a patient in use, and a second composition part in the form of a powder for nasal application to the patient in use. The first and second composition parts are applied to the patient separately or together as required.