Nasal Delivery Device Two-Step Compressed Gas Mechanism
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Solution Overview
Problem
Existing nasal substance delivery devices face challenges in delivering medicaments to the central and upper sections of the nasal passages, such as the middle and upper turbinates, due to difficulties in targeting specific areas, variability in absorption rates, and requirements for coordination of breathing and strength, which limits their effectiveness and user compliance.
Innovation Solution
A two-step mechanism utilizing a nosepiece connected to an air-tight enclosure with a predetermined volume of compressed gas, which is pressurized to a specific pressure, allowing for precise and consistent delivery of a flowable substance to the nasal passages without requiring user coordination of breathing, ensuring reproducible dosing and targeting of the upper turbinates and potentially the brain.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If existing nasal substance delivery devices are used, then medicaments can be delivered to the nasal passages, but the delivery precision to central and upper sections (middle and upper turbinates) is insufficient and absorption rates vary significantly
Solution Approach 1:
The patent applies parameter changes by controlling the pressure (2-20 psi), volume (nasal cavity volume range), and temperature of the compressed air carrier gas to optimize medicament delivery. By adjusting these physical parameters, the system achieves precise targeting of central and upper nasal sections while maintaining consistent absorption rates across different users and conditions
2Ease of operation
If devices requiring breathing coordination are used, then medicament delivery can be achieved, but user compliance is reduced due to the need for coordination of breathing and activation
Solution Approach 1:
The system employs a self-service mechanism where the user simply activates the device without needing to coordinate breathing. The compressed air carrier gas automatically delivers the medicament to the nasal passages, eliminating the need for complex breathing coordination and significantly improving ease of operation and user compliance
3Measurement precision
If compressed air is used as a carrier to deliver medicament to the nasal cavity, then precise and consistent delivery to specific areas is achieved, but the device requires a source of compressed gas which increases device complexity
Solution Approach 1:
The system segments the compressed gas function into a separate, portable reservoir that can be recharged externally. This allows the main delivery mechanism to remain simple while the gas storage and pressurization functions are handled by a reusable cartridge system, reducing overall device complexity while maintaining precise targeting capabilities
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The solution enables precise and consistent delivery of medicaments to the nasal passages, including the upper turbinates, with controlled air volume, pressure, and speed, improving absorption rates and user compliance by eliminating the need for breathing coordination and ensuring delivery to specific areas within the nasal cavity.
Implementation Method 1
the use of compressed air to carry/entrain flowable substance to the nasal passages
Implementation Method 2
the volume of the air being compressed is in the range of the nasal cavity volume
Data Source
AI summary
The present invention provides a two-step mechanism for delivering a flowable substance to the nasal passages, comprising: a. a nosepiece adapted to be in fluid connection with said nasal passages; b. at least one air-tight enclosure, comprising predetermined amount of compressed gas in the same; said compressed gas is pressurized to predetermined amount of pressure; c. a charging mechanism, fluidly connected with said air-tight enclosure, characterized by at least two configurations: a retracted position and an extended position; where, when said charging mechanism is transformed from said extended position to said retracted position, said charging mechanism is adapted to enable delivery of said pressurized and predetermined amount of compressed gas from at least one first predetermined position in said air-tight enclosure to at least one second predetermined position; d. an activation mechanism, adapted to entrain said flowable substance within said pressurized and predetermined amount of compressed gas.