In-Line Nasal Delivery Device Olfactory Targeting
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Solution Overview
Problem
The complex architecture of the nasal cavity and turbinate structures hinder effective deposition of drugs on the olfactory region, leading to absorption into the bloodstream instead of the central nervous system, limiting the efficacy of nasal delivery methods.
Innovation Solution
An in-line nasal delivery device featuring a y-junction design with a metered dose pump, propellant canister, and nozzle system that facilitates precise delivery of compounds to the olfactory region by converting liquefied propellant to gas and using a diffuser to ensure compound deposition beyond the nasal valve.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If nasal drop or spray devices are used to saturate the lower nasal cavity, then drug delivery to the nasal cavity is achieved, but the drug is absorbed into the bloodstream instead of reaching the CNS, eliminating the advantage of nasal route for CNS delivery
Solution Approach 1:
The device segments the nasal cavity delivery path into distinct zones: the lower nasal cavity and the olfactory region. By using a specialized nozzle assembly with specific geometry and orientation, the device delivers drug to different regions separately, ensuring that CNS-targeted drugs reach the olfactory region while other drugs can saturate the lower nasal cavity for systemic absorption.
Solution Approach 2:
The nozzle assembly is designed with local quality variations - specific opening angles, orientations, and positions that create different spray patterns for different nasal regions. The device incorporates features like adjustable nozzle angles and multiple spray outlets that can be optimized for either olfactory region targeting or lower nasal cavity saturation based on the specific therapeutic need.
2Reliability
If the nasal cavity architecture and turbinate structures are present, then natural protection of the CNS entry way is provided, but effective deposition of drugs on the olfactory region becomes difficult to accomplish
Solution Approach 1:
The device performs preliminary action by pre-positioning the nozzle assembly to align with the olfactory region before drug delivery. The adjustable nozzle mechanism allows the user to pre-adjust the spray direction and angle to account for individual anatomical variations in nasal cavity structure, ensuring that the drug is deposited accurately on the olfactory region despite the complex nasal architecture.
Solution Approach 2:
The device addresses the three-dimensional complexity of the nasal cavity by introducing angular and orientational dimensions to the spray delivery. The nozzle assembly can be adjusted in multiple directions and angles, allowing the drug to be delivered along different paths that navigate around the turbinate structures and reach the olfactory region effectively.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The device effectively delivers compounds to the olfactory region, enhancing the intranasal delivery of pharmaceuticals and improving CNS targeting by utilizing a combination of mechanical and propellant-driven mechanisms for precise compound deposition.
Implementation Method 1
converting liquefied propellant to gas and using a diffuser to ensure compound deposition beyond the nasal valve
Implementation Method 2
using a diffuser to ensure compound deposition beyond the nasal valve
Data Source
AI summary
A delivery device for a compound including: a housing, vial holding a compound; and a source of propellant, wherein the housing provides an inlet and an outlet for the vial, wherein the inlet is in fluid communication with the source of propellant and is directed against the compound and the outlet allows for delivery of the compound.