Nasal Dispensing Device with Conical Well for Rhinitis Treatment
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Solution Overview
Problem
There is a need for an easy-to-use, efficient, and reliable dispensing device for nasal administration that provides superior efficacy in treating rhinitis, particularly one that consistently delivers a combination of mometasone and olopatadine for effective symptom relief.
Innovation Solution
A dispensing device with a pharmaceutical composition containing mometasone, an ester thereof (e.g., mometasone furoate), or a salt thereof, and olopatadine or a salt thereof (e.g., olopatadine hydrochloride), featuring a container with a dip tube and a dispenser head that includes a pump or valve mechanism, a dispensing channel, and a dispensing orifice, which delivers a stable suspension with a hydrocolloid to maintain viscosity and prevent phase separation, ensuring consistent dosing and improved stability.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If a simple container is used for nasal administration, then device complexity is reduced, but dosing consistency and delivery reliability cannot be achieved
Solution Approach 1:
The dispensing device is divided into distinct functional components: a container for holding the pharmaceutical composition, a dip tube for delivering the composition, and a dispenser head with pump/valve mechanism for controlled dispensing. This segmentation allows each component to perform its specific function reliably while maintaining overall system manageability.
Solution Approach 2:
The dip tube acts as an intermediary element connecting the container to the dispenser head, ensuring reliable transfer of the pharmaceutical composition from the storage container to the dispensing mechanism. This intermediary component enables consistent dosing by controlling the flow path and preventing direct contact between the user and the medication reservoir.
2Stability of the object's composition
If a hydrocolloid suspension is used to maintain viscosity and prevent phase separation, then stability is improved, but manufacturing precision is required to achieve proper viscosity range
Solution Approach 1:
The viscosity of the pharmaceutical composition is controlled by adjusting the concentration of hydrocolloid within a specific range (10-200 cps). This parameter change allows the formulation to maintain suspension stability while enabling consistent dispensing through the device's pump and valve mechanisms.
Solution Approach 2:
The pharmaceutical composition uses a composite formulation combining mometasone (in particulate or dissolved form), olopatadine (in dissolved form), and hydrocolloid. This composite material approach allows the different components to work together: the active ingredients provide therapeutic effect while the hydrocolloid provides suspension stability and viscosity control.
3Reliability
If a conically shaped container bottom with deepened well is used, then dosing consistency is improved by preventing residue, but device complexity increases
Solution Approach 1:
The container bottom is designed with a conical shape that curves downward to a central well, creating a geometry that naturally directs remaining pharmaceutical composition toward the dip tube opening. This curved geometry prevents medication residue from stagnating in flat areas, ensuring consistent dosing throughout the product's shelf life.
4Measurement precision
If a pump or valve mechanism is included in the dispenser head, then dosing precision is achieved, but ease of operation may be reduced
Solution Approach 1:
The pump or valve mechanism in the dispenser head is designed to automatically control the dispensing of the pharmaceutical composition when the device is actuated. The mechanism self-regulates the flow rate and dosage amount, eliminating the need for the user to manually measure or control the dispensing parameters, thereby maintaining ease of operation while ensuring dosing precision.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The device achieves consistent and stable delivery of the active ingredients, providing faster onset of action and improved symptom relief for allergic rhinitis, with the hydrocolloid maintaining suspension stability and preventing phase separation, ensuring effective treatment over time.
Implementation Method 1
the pharmaceutical composition is an aqueous suspension containing a hydrocolloid, where the mometasone is present in particulate form and the olopatadine is in dissolved form
Implementation Method 2
the hydrocolloid maintaining suspension stability and preventing phase separation
Implementation Method 3
a dip tube extending along the longitudinal axis of the container, the dip tube having a proximal end communicating with the dispenser head and an open distal end extending into the container
Implementation Method 4
the distal end of the dip tube can extend into the well, or can be located at a top of the well
Implementation Method 5
The container has a conically shaped internal bottom, where the internal bottom is angled downwardly from a side of the container toward a center
Data Source
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AI summary
A nasal dispensing device and pharmaceutical composition includes a container; a dispenser head having at least a pump, a dispensing channel, and a dispensing orifice; a dip tube; and a pharmaceutical composition comprising mometasone, an ester thereof (e.g., mometasone furoate), or a salt thereof and olopatadine or its salt (e.g., olopatadine hydrochloride). The container can have a conically shaped internal bottom, angled downwardly toward a center, and a further angularly deepened well, centrally located, with the dip tube extending into the well. An optional cap is provided that includes a sealing sleeve communicating in a seal tight manner with a perimeter of a lateral wall of the dispenser head.