Nasal Dispensing Device with Conical Well for Rhinitis
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Solution Overview
Problem
There is a need for an easy-to-use, efficient, and reliable dispensing device for nasal administration that provides superior efficacy in treating rhinitis, particularly for allergic rhinitis, using a pharmaceutical composition containing mometasone and olopatadine.
Innovation Solution
A dispensing device with a pharmaceutical composition comprising mometasone, an ester thereof (e.g., mometasone furoate), or a salt thereof and olopatadine, or a salt thereof (e.g., olopatadine hydrochloride), which includes a container, a dispenser head with a pump or valve mechanism, a dip tube, and a cap, designed to deliver a consistent dose of the medication as a nasal spray, utilizing a hydrocolloid to maintain stability and prevent phase separation.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If a pharmaceutical composition containing mometasone and olopatadine is used for treating rhinitis, then the efficacy is improved, but the device complexity increases
Solution Approach 1:
The patent combines two active ingredients (mometasone and olopatadine) into a single pharmaceutical composition delivered by one dispensing device, merging multiple treatments into one unified system that improves efficacy while maintaining manageable complexity through integrated design
Solution Approach 2:
The dispensing device is designed to deliver a combination therapy for multiple symptoms of rhinitis simultaneously, making the device multi-functional in treating different aspects of the condition with a single administration system
2Reliability
If a consistent dosing system is implemented, then the reliability of treatment is improved, but the manufacturing precision requirements increase
Solution Approach 1:
The patent specifies precise concentration ranges for mometasone (0.001%-0.075% w/w) and olopatadine (0.5%-0.8% w/w) in the pharmaceutical composition, using controlled parameter specifications to achieve consistent dosing while managing manufacturing precision through defined tolerances
3Duration of action of stationary object
If the pharmaceutical composition is stored for extended periods, then the availability for treatment is improved, but the stability of the composition deteriorates
Solution Approach 1:
The patent incorporates stabilizing excipients and preservatives into the pharmaceutical composition during manufacturing, performing preliminary protective actions that prevent degradation and maintain composition stability throughout extended storage periods
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The device ensures consistent and effective delivery of mometasone and olopatadine, providing faster onset of action for symptom relief in allergic rhinitis, with improved stability and reduced impurities, ensuring reliable treatment over extended storage periods.
Implementation Method 1
utilizing a hydrocolloid to maintain stability and prevent phase separation
Data Source
AI summary
A nasal dispensing device and pharmaceutical composition includes a container; a dispenser head having at least a pump, a dispensing channel, and a dispensing orifice; a dip tube; and a pharmaceutical composition comprising mometasone, an ester thereof (e.g., mometasone furoate), or a salt thereof and olopatadine or its salt (e.g., olopatadine hydrochloride). The container can have a conically shaped internal bottom, angled downwardly toward a center, and a further angularly deepened well, centrally located, with the dip tube extending into the well. An optional cap is provided that includes a sealing sleeve communicating in a seal tight manner with a perimeter of a lateral wall of the dispenser head.