Nasal Gel Composition for Epistaxis Hemostasis

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Solution Overview

Problem

Current treatments for epistaxis, such as nasal packing with cotton tampons or inflatable balloons, are inconvenient, painful, and can lead to infection, and existing nasal sprays and gels have not effectively addressed the need for a non-invasive, effective solution for recurring and severe nosebleeds.

Innovation Solution

A gel composition comprising carboxy polymethylene polymer, glycine, and a source of calcium ions, which is administered nasally to exert pressure, reduce blood flow, and promote coagulation, thereby effectively treating epistaxis without the need for removal and minimizing discomfort.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If cotton tampons or inflatable balloons are used to treat epistaxis, then bleeding is stopped by applying pressure to the nasal mucosa, but the treatment causes pain, interferes with normal breathing, and may lead to local infection

Engineering Contradiction:

Improvehemostatic effectVSAvoidpain and infection risk

Core Design Contradiction:

ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The patent replaces the mechanical packing system (cotton tampons, balloons) with a chemical/coagulation-based system. The gel composition contains tranexamic acid (fibrinolytic inhibitor) and adrenaline (vasoconstrictor) that work chemically to promote clotting and reduce bleeding, eliminating the need for mechanical pressure application that causes pain and infection risk

Inventive Principle:

Principle #28Mechanics substitution (Replace mechanical system)

Solution Approach 2:

The patent changes the physical state and concentration parameters by using a gel formulation with specific viscosity and drug concentrations. The gel has optimal viscosity to remain in place without mechanical support, and contains precisely controlled concentrations of tranexamic acid (0.1-5%) and adrenaline (0.01-0.1%) to achieve hemostasis without the harmful effects of mechanical packing

Inventive Principle:

Principle #35Parameter changes

2Reliability

If cotton tampons are inserted into the nose to stop bleeding, then pressure is applied to the nasal mucosa, but the treatment is painful and interferes with normal breathing

Engineering Contradiction:

Improvebleeding controlVSAvoidpatient comfort

Core Design Contradiction:

ReliabilityVSEase of operation

Solution Approach 1:

The mechanical pressure application of cotton tampons is replaced with a pharmacological approach using tranexamic acid to inhibit fibrinolysis and adrenaline to constrict blood vessels. This chemical mechanism achieves bleeding control without mechanical pressure, eliminating pain and breathing interference

Inventive Principle:

Principle #28Mechanics substitution (Replace mechanical system)

Solution Approach 2:

The patent uses the gel's rheological properties (viscosity, elasticity) to achieve self-retention in the nasal cavity without mechanical support. The gel flows into the bleeding area and remains in place due to its viscoelastic characteristics, eliminating the need for tampon pressure while maintaining hemostatic effect

Inventive Principle:

Principle #29Pneumatics and hydraulics

3Reliability

If intranasal packing is employed to treat severe epistaxis, then bleeding is controlled, but the packing may stay in place for 1-4 days causing inconvenience and discomfort

Engineering Contradiction:

Improvehemostatic effectVSAvoidremoval time

Core Design Contradiction:

ReliabilityVSLoss of time

Solution Approach 1:

The patent replaces mechanical packing that requires removal after 1-4 days with a pharmacological gel formulation. The gel promotes clotting through tranexamic acid and adrenaline action, and is naturally cleared by the body's mucociliary apparatus within hours, eliminating the need for manual removal and associated discomfort

Inventive Principle:

Principle #28Mechanics substitution (Replace mechanical system)

Solution Approach 2:

The gel composition is designed to be self-clearing through the body's natural mucociliary clearance mechanism. The gel remains in place long enough to achieve hemostasis (several hours) and then is naturally transported out of the nasal cavity by ciliary action, eliminating the need for patient intervention or clinical removal procedures

Inventive Principle:

Principle #25Self-service

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The gel composition effectively stops nosebleeds by applying pressure and promoting coagulation, is easily administered and removed by the body, reducing the risk of infection and discomfort, and is more effective than previous treatments.

Implementation Method 1

a carboxy polymethylene polymer; and water

Methodology Applied

Scientific EffectHydrogel formation: Gel

Implementation Method 2

glycine; and a source of calcium ions

Methodology Applied

Scientific EffectCoagulation: Coagulation

Data Source

PatentEP2117502B1Composition for combating epistaxis

Publication Date: 2016.11.09 PHARMACURE HEALTH CARE

AI summary

The invention relates to a gel composition comprising: a) a carboxy polymethylene polymer; b) glycine; c) a source of calcium ions; and d) water. The invention also extends to a dry composition comprising the aforementioned components a), b) and c). The gel compositions of the invention are useful for the prophylaxis and treatment of epistaxis. The gel compositions can be easily administered to the nasal cavity and do not require removal after use.