Nasal Insert Assembly for Prolonged Local Drug Delivery
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Solution Overview
Problem
Current nasal swabs are not designed for prolonged contact within the nasal passage to effectively deliver medicinal substances, leading to inefficient delivery of pharmaceuticals.
Innovation Solution
A nasal passage insert assembly comprising absorbent plugs pre-saturated with medicinal substances, designed for temporary placement within the nasal cavity, featuring tunnels for airflow and retrieval features, allowing prolonged contact and localized delivery of active agents.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Duration of action of moving object
If swabs are used for nasal passage treatment, then the nasal passage can be cleaned or treated temporarily, but the swabs cannot remain in the nasal passage for a sufficient period to allow proper delivery of medicinal substances
Solution Approach 1:
The patent employs a disposable insert that is discarded after a single use, eliminating the need for cleaning or repositioning. This disposable nature allows the insert to remain in the nasal passage for the full required duration (typically several hours) without concern for hygiene or comfort issues that would arise with reusable swabs, thereby achieving both prolonged contact time and ease of operation.
Solution Approach 2:
The insert is constructed with a flexible, conformable structure that adapts to the nasal passage anatomy. This flexibility allows the insert to maintain secure retention and continuous contact with the nasal mucosa throughout the treatment period, preventing dislodgement while remaining comfortable for the patient, thus resolving the contradiction between retention and ease of operation.
2Productivity
If medicinal substances are delivered via inhalation through tunnels, then the substance can be delivered systemically, but localized delivery to the nasal mucosal surface is reduced
Solution Approach 1:
The insert incorporates distinct zones with different functional properties: the outer surface is designed for localized delivery to the nasal mucosa, while internal tunnels are configured for inhalation delivery. This spatial differentiation of delivery modes allows both localized and systemic administration to occur simultaneously, resolving the trade-off between delivery efficiency and localized substance quantity.
Solution Approach 2:
The insert structure is segmented into multiple functional regions including external medicinal substance reservoirs for localized delivery and internal tunnels for inhalation delivery. This segmentation enables independent optimization of each delivery pathway, allowing the device to achieve both high productivity through inhalation and adequate localized delivery to the nasal mucosa.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Facilitates continuous and localized administration of medicinal substances directly to the nasal mucosal surface, enhancing delivery efficiency and comfort by maintaining plug retention and minimizing evaporation loss.
Implementation Method 1
The first insert member is made of an absorbent material and includes a medicinal substance therein
Implementation Method 2
The inserts are shaped to fit snuggly in a human's nostril(s) and are soaked in or at least partially saturated with a medicinal liquid
Data Source
AI summary
A nasal passage insert packaging assembly that includes at least a first insert member that is configured to be received in a first nasal passage. The first insert member is made of an absorbent material and includes a medicinal substance therein. The assembly includes a container that defines a container interior. The first insert member is disposed in the container interior and the container is scaled.