Nasal Composition with Thixotropic Barrier and Anti-Allergic Oil
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Solution Overview
Problem
Current treatments for allergic rhinitis, such as allergen restriction, medicamentous therapy, and specific immunotherapy, are either cumbersome, expensive, or lack sustained effectiveness, and existing nasal sprays are not effective once symptoms are present.
Innovation Solution
A nasal composition combining anti-allergic oil derived from Perilla spp. with an oil-based barrier-forming preparation containing sesame oil, gel formers like xanthan gum, and an aqueous base, which forms a thixotropic gel barrier to inhibit mast cell activation and histamine release.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If a thixotropic nasal spray is used to form a physical barrier in the nasal cavity, then allergen exposure is reduced and mast cell contact is prevented, but the preparation is not effective when disruptive rhinitis symptoms are already present
Solution Approach 1:
The patent combines two distinct functional components into a single nasal spray preparation: (1) a thixotropic barrier-forming preparation that creates a physical barrier against allergens, and (2) an anti-allergic active substance (such as cromolyn sodium or nedocromil sodium) that directly treats mast cell activation. This merging allows the preparation to serve both prophylactic and therapeutic functions simultaneously, resolving the contradiction between being effective for prevention versus being effective for treating existing symptoms.
2Reliability
If allergen restriction measures are implemented, then exposure to allergens is reduced and mast cell activation is prevented, but high compliance levels are required from patients and surroundings
Solution Approach 1:
The nasal spray preparation provides self-service by directly delivering anti-allergic protection to the nasal mucosa without requiring patients to modify their lifestyle or environment. The active substances in the spray directly inhibit mast cell activation and reduce allergic responses, eliminating the need for complex allergen restriction measures such as keeping windows closed, using pollen filters, or avoiding outdoor activities. This resolves the contradiction by making the solution easy to use while maintaining high effectiveness.
3Reliability
If medicamentous therapy is used for allergic rhinitis, then symptomatic relief is provided, but the therapy is considerably elaborate and expensive
Solution Approach 1:
The patent merges the barrier-forming function with anti-allergic pharmacological action in a single preparation, eliminating the need for multiple separate treatments. The thixotropic vehicle provides physical barrier protection while the incorporated anti-allergic substances (cromolyn sodium, nedocromil sodium, or other mast cell stabilizers) provide pharmacological symptom relief. This combined approach simplifies the therapy regimen compared to using separate barrier preparations and medicaments, reducing complexity while maintaining comprehensive effectiveness.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The nasal composition provides enhanced prophylactic and therapeutic effects by reducing histamine concentration in tissues by at least 20%, offering improved sprayability and barrier function to prevent allergen contact with nasal mucosa, thereby effectively managing allergic rhinitis symptoms.
Implementation Method 1
the oil-based barrier-forming preparation is capable of forming a physical barrier in the nasal cavity
Implementation Method 2
inhibit activation of mast cells... inhibit mast cell activation and histamine release
Data Source
Figure 1(a)~1(b)
Figure 1(c)~1(d)
Figure 1(e)~2
AI summary
The present invention relates to a nasal composition comprising an anti-allergic oil derived from plant; and an oil-based barrier-forming preparation. The composition may be used in preventing and/or treating allergic disorders of the nasal cavity, including seasonal allergic rhinitis (hay fever) and perennial allergic rhinitis.