Nasal Trigger Assembly With Spring Activator Against Accidental Actuation

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Solution Overview

Problem

Existing nasal delivery devices for administering glucagon in emergency situations are complex to use and prone to accidental actuation, posing a risk of errors and inefficiency in treating severe hypoglycemia.

Innovation Solution

A nasal delivery device with a trigger assembly, a spring-loaded activator, and a drug container system that includes a push rod mechanism to securely dispense medication without requiring reconstitution, featuring a safety mechanism to prevent accidental actuation and reduced actuation force.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Ease of operation

If a nasal delivery device is designed to be easy to use in emergency situations, then ease of operation is improved, but the device may become prone to accidental actuation

Engineering Contradiction:
Improveease of useVSAvoidaccidental actuation risk
Core Design Contradiction:
Ease of operationVSReliability

Solution Approach 1:

The device incorporates a safety mechanism with a safety tab and safety aperture that must be deliberately removed or moved to allow actuation. This preliminary anti-action prevents accidental activation by requiring a conscious, deliberate action to bypass the safety feature, thus resolving the contradiction between ease of use and prevention of accidental actuation.

Inventive Principle:
Principle #9Preliminary anti-action

Solution Approach 2:

The device requires a two-step activation process: first removing or moving the safety tab to expose the trigger mechanism, then pressing the trigger. This preliminary action ensures that the device cannot be accidentally activated, as the safety feature must be deliberately disengaged first, maintaining both ease of intended use and protection against accidental actuation.

Inventive Principle:
Principle #10Preliminary action

2Reliability

If a nasal delivery device includes complex safety mechanisms to prevent accidental actuation, then reliability is improved, but device complexity increases

Engineering Contradiction:
Improveaccidental actuation preventionVSAvoidmechanism complexity
Core Design Contradiction:
ReliabilityVSDevice complexity

Solution Approach 1:

The safety mechanism is designed as a separate, removable safety tab that can be taken out or moved to activate the device. This extraction approach simplifies the overall mechanism by using a discrete safety component rather than a complex integrated system, resolving the contradiction between reliability and device complexity.

Inventive Principle:
Principle #2Taking out (Extraction)

Solution Approach 2:

The safety tab is designed as a simple, disposable component that is removed or destroyed during the activation process. This approach uses a simple, low-complexity element to provide robust safety functionality, avoiding the need for complex, reusable safety mechanisms and thus resolving the contradiction between reliability and device complexity.

Inventive Principle:
Principle #27Cheap short-living objects (Disposable)

3Speed

If a nasal delivery device uses a spring-loaded activator for rapid medication delivery, then speed of delivery is improved, but the device requires more force for actuation

Engineering Contradiction:
Improvemedication delivery speedVSAvoidactuation force
Core Design Contradiction:
SpeedVSForce

Solution Approach 1:

The spring-loaded activator is pre-compressed and stored in an energized state during device assembly and shipping. This preliminary action stores mechanical energy that is released during actuation, providing rapid medication delivery without requiring the user to apply significant force, thus resolving the contradiction between delivery speed and actuation force.

Inventive Principle:
Principle #10Preliminary action

Solution Approach 2:

The spring mechanism performs the work of rapid medication delivery automatically once triggered, without requiring the user to continue applying force. The stored elastic energy in the spring self-generates the force needed for rapid ejection, resolving the contradiction between speed and actuation force by making the system self-powered after initial triggering.

Inventive Principle:
Principle #25Self-service

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The device provides a user-friendly, reliable, and secure means to administer medication, ensuring accurate delivery with minimal effort and preventing accidental discharge, thus addressing the challenges of complexity and safety in existing devices.

Implementation Method 1

an elastic activator device configured to bias the push rod to open the first seal and to drive movement of the drug container towards the outlet end

Methodology Applied
Scientific EffectElasticity: Elasticity

Data Source

PatentUS12508377B2Nasal delivery device with trigger and spring-loaded activator
Publication Date: 2025.12.30 ELI LILLY & CO
  • US12508377B2 patent drawing
  • US12508377B2 patent drawing
  • US12508377B2 patent drawing

AI summary

The present disclosure provides a nasal delivery device with a device body that includes a trigger end and an outlet end. The nasal delivery device also includes a trigger assembly coupled to the trigger end of the device body, a drug container supported by the device body, and a spring-loaded activator assembly supported by the device body and disposed between the trigger assembly and the drug container.