Natural Additive Composition for Stable Particle Pores in Tablets

Resolve Bottlenecks,
Find Innovative SolutionsGenerate Solutions

Solution Overview

Problem

The health food industry faces challenges in manufacturing products with natural ingredients due to issues such as poor fluidity, weight deviation, and machine sticking caused by synthetic additives, despite efforts to replace them with natural alternatives.

Innovation Solution

A naturally derived additive composition using jujube extract or jujube powder, combined with excipients like maltodextrin and crystalline cellulose, is formulated to stabilize particle pores and improve hardness, disintegration, and lubricity in tablet production.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Ease of operation

If synthetic additives (stearic acid, magnesium stearate, silicon dioxide) are used to improve fluidity and lubrication, then tabletting performance is improved, but natural ingredient requirement is compromised

Engineering Contradiction:

Improvetabletting performanceVSAvoidnatural ingredient requirement

Core Design Contradiction:

Ease of operationVSAdaptability or versatility

Solution Approach 1:

The patent changes the chemical composition parameters by replacing synthetic additives with natural alternatives. Specifically, it uses jujube extract (containing natural compounds like flavonoids and phenolic acids) instead of stearic acid/magnesium stearate, and natural anti-caking agents instead of silicon dioxide, thereby meeting natural ingredient requirements while maintaining functionality

Inventive Principle:

Principle #35Parameter changes

Solution Approach 2:

The patent employs readily available natural materials (jujube extract, natural anti-caking agents) that can be easily sourced and processed, replacing expensive or complex synthetic additives. These natural materials are used in small amounts (0.1-5% binder, 0.01-1% lubricant, 0.1-5% anti-caking agent) to achieve the desired effect

Inventive Principle:

Principle #27Cheap short-living objects (Disposable)

2Adaptability or versatility

If natural additives are used to meet natural ingredient requirements, then natural ingredient requirement is satisfied, but tabletting performance (fluidity, lubrication) deteriorates

Engineering Contradiction:

Improvenatural ingredient requirementVSAvoidtabletting performance

Core Design Contradiction:

Adaptability or versatilityVSEase of operation

Solution Approach 1:

The patent creates a composite formulation system combining multiple natural components: jujube extract (providing binding and lubricating properties), natural anti-caking agents (providing flowability), and excipients. This composite approach allows each component to contribute its specific functionality, collectively achieving tabletting performance comparable to synthetic additives

Inventive Principle:

Principle #40Composite materials

Solution Approach 2:

The jujube extract acts as an intermediary substance that provides both binding and lubricating functions simultaneously. Its natural compounds (flavonoids, phenolic acids) mediate between particle adhesion and surface slip, reducing the need for separate synthetic binder and lubricant additives

Inventive Principle:

Principle #24Intermediary (Mediator)

3Stability of the object's composition

If granules are over-dried in wet granulation process, then moisture control is improved, but fine powder generation increases causing poor fluidity and weight deviation

Engineering Contradiction:

Improvemoisture controlVSAvoidfluidity and weight uniformity

Core Design Contradiction:

Stability of the object's compositionVSManufacturing precision

Solution Approach 1:

The patent applies binder and anti-caking agents before the drying step to prepare the granule structure in advance. The binder promotes proper granule formation and the anti-caking agent prevents excessive fine powder generation during subsequent drying and sizing operations, thereby maintaining fluidity and weight uniformity

Inventive Principle:

Principle #10Preliminary action

Solution Approach 2:

The patent converts the potentially harmful effect of drying (which can cause fine powder generation) into a beneficial process by using anti-caking agents that protect against fine powder formation. The controlled drying process, combined with these agents, actually improves granule stability while preventing the generation of problematic fine particles

Inventive Principle:

Principle #22Blessing in disguise (Convert harm into benefit)

Data Source

PatentUS12508230B2Additive composition for formulation capable of stabilizing pore of solid particles and method for production thereof

Publication Date: 2025.12.30 NPK INC

AI summary

The present invention relates to an additive composition, and more particularly, to an additive composition capable of stabilizing pores of particles in a solid formulation. The present invention provides an additive composition including a naturally derived raw material, which enables formulation without using any synthetic additives. Further, the present invention provides an additive composition in which particles are uniformly distributed by reducing pores of particles in a formulation, as well as tablets, powders or the like including the same.