Natural Granulate Composition for Tablet Flow and Compressibility
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Solution Overview
Problem
There is a need to replace synthetic or semisynthetic tablet excipients with all-natural components while maintaining plastic deformability and excellent flow properties, as consumers increasingly prefer natural formulations, and synthetic excipients like lactose may cause intolerance.
Innovation Solution
A method involving a high-shear mixer process to combine a carrier powder from plant materials with an organic syrup to create a granulate, ensuring an angle of repose of at most 45° and a loss on drying between 10-70 wt%, resulting in a granulate with excellent flowability and plasticity.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If synthetic or semisynthetic tablet excipients like lactose are used, then excellent flowability and good plasticity are achieved, but consumer preference decreases due to intolerance and desire for natural formulations
Solution Approach 1:
The patent changes the chemical composition parameters by replacing synthetic excipients with natural plant-based carriers. Specifically, it uses plant materials such as rice hulls, corn cob powder, or wheat straw powder as carriers, combined with natural binders like starch or cellulose derivatives, thereby maintaining functional properties while eliminating synthetic ingredients that cause consumer intolerance.
Solution Approach 2:
The patent employs composite material formulation by combining plant-based carrier materials with natural binders and lubricants. This composite approach allows the mixture to achieve the necessary flowability and plasticity properties typically provided by synthetic excipients, while using only natural, consumer-friendly ingredients.
2Object-affected harmful factors
If all-natural plant-based carrier materials are used, then consumer acceptance and safety improve, but flow properties and plastic deformability may deteriorate
Solution Approach 1:
The patent optimizes physical parameters such as particle size distribution, moisture content, and density of the plant-based carrier materials. By controlling these parameters, the formulation achieves improved flow properties and compressibility while maintaining the natural ingredient composition that ensures consumer safety and preference.
Solution Approach 2:
The patent creates composite formulations combining multiple natural ingredients including plant-based carriers, natural binders (starch, cellulose), and natural lubricants. This composite structure synergistically enhances flowability and plastic deformability of individual plant-based materials that may otherwise exhibit poor handling characteristics.
3Object-affected harmful factors
If natural organic syrup is used as binder instead of synthetic materials, then product safety and natural formulation are improved, but manufacturing precision and consistency may be challenged
Solution Approach 1:
The patent establishes precise parameter specifications for the organic syrup binder including viscosity range, moisture content, and composition standards. By controlling these parameters, the manufacturing process achieves consistent granulate formation and uniform product quality while using natural organic binders instead of synthetic materials.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The granulate exhibits good flow properties, non-reactivity, compressibility, and safety, allowing for uniform filling and strong tablet formation, suitable for pharmaceutical and dietary supplements, while being cost-effective and compatible with various manufacturing processes.
Implementation Method 1
A method involving a high-shear mixer process to combine a carrier powder from plant materials with an organic syrup to create a granulate
Implementation Method 2
The granulate exhibits good flow properties, non-reactivity, compressibility, and safety, allowing for uniform filling and strong tablet formation
Implementation Method 3
resulting in a granulate with excellent flowability and plasticity
Implementation Method 4
ensuring an angle of repose of at most 45°
Data Source
AI summary
The present disclosure relates to a method of producing a granulate based on all-natural ingredients, a granulate obtainable by said method, and its use as a tableting excipient and for the production of other oral solid dosage forms such as capsules having excellent flow properties and excellent compressibility. The method includes the steps of introducing a carrier powder from a plant material into a high-shear mixer granulator, wherein the carrier material exhibits an angle of repose (AoR), as measured according to the fixed funnel method using a plastic funnel with a distance of 7 cm drop height to a 10 cm diameter disk, of at most 45°, preferably of at most 40°, such as between 30° and 45°, preferably between 35° and 40°; introducing a syrup—component (b)—into the mixer while mixing under high shear, where the organic syrup has a loss on drying (LoD) between 10 wt. % and 70 wt %, preferably between 15 wt. % and 30 wt. %, based on the total weight of the syrup; mixing the components in the high shear mixer to produce a granulate.