Natural Polymer Tissue Adhesive for Wet Tissue Bonding
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Solution Overview
Problem
Current tissue adhesives for internal use face challenges such as toxicity, poor mechanical strength, risk of viral infection, and irritation, particularly in applications like tonsillectomy and adenoidectomy surgeries where adhesion to wet tissue is required without causing choking hazards.
Innovation Solution
A tissue adhesive formed from a mixture of natural polymers, specifically chitosan and sodium alginate, combined with a dilute acid solution as an activating agent, which enhances adhesive properties and promotes wound healing, while being biocompatible and biodegradable.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Strength
If cyano-acrylates are used as tissue adhesive, then adhesive strength is improved, but toxicity increases making it unsuitable for internal use
Solution Approach 1:
The patent changes the chemical composition parameters from synthetic cyano-acrylates to natural polymers (chitosan, alginate, gelatin) that provide adequate adhesive strength while being biocompatible and biodegradable, thus eliminating toxicity issues while maintaining functional performance
Solution Approach 2:
The patent creates a composite tissue adhesive formulation combining multiple natural polymers (chitosan, alginate, gelatin) with complementary properties - chitosan provides adhesion and antimicrobial activity, alginate provides gel structure and hemostasis, and gelatin provides biocompatibility and wound healing promotion, achieving both strength and safety
2Object-affected harmful factors
If fibrin-based adhesives are used, then biocompatibility is improved, but mechanical strength deteriorates
Solution Approach 1:
The patent combines fibrin with other natural polymers (chitosan, alginate) to create a composite adhesive that maintains the biocompatibility of fibrin while gaining enhanced mechanical strength and durability from the additional polymer components
3Strength
If current starch-based adhesives are used, then adhesion is improved, but bio-compatibility deteriorates due to cross-linking agents
Solution Approach 1:
The patent changes the cross-linking mechanism from chemical cross-linking agents (which cause irritation) to physical cross-linking through ionic interactions between natural polymers (such as calcium ions cross-linking alginate), achieving strong adhesion while maintaining biocompatibility
Solution Approach 2:
The patent uses naturally-derived, biodegradable polymers that are absorbed by the body over time, eliminating the need for permanent cross-linking agents and reducing long-term irritation risks
4Strength
If tissue adhesive is applied to wet tissue in tonsillectomy surgery, then adhesion is required, but choking hazard increases if additional adhesives are used
Solution Approach 1:
The patent creates a multi-functional tissue adhesive that provides adhesion, hemostasis, and wound healing promotion in a single formulation, eliminating the need for additional separate adhesive applications that could increase choking hazard in tonsillectomy surgery
Solution Approach 2:
The patent formulates the adhesive with optimized viscosity and adhesion characteristics that enable effective bonding to wet tissue surfaces without requiring thick or problematic additional adhesive layers, reducing choking risk
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The adhesive demonstrates increased adhesion strength, accelerated wound healing, and durability in moist environments, making it suitable for post-surgical applications without the need for additional adhesives, thus reducing the risk of irritation and choking hazards.
Implementation Method 1
a tissue adhesive formed from a mixture of natural polymers, specifically chitosan and sodium alginate
Implementation Method 2
a tissue adhesive formed from a mixture of natural polymers in combination with an activating agent that enhances the adhesive properties
Implementation Method 3
combined with a dilute acid solution as an activating agent, which enhances adhesive properties
Implementation Method 4
an activating agent that enhances the adhesive properties of the natural polymer mixture
Implementation Method 5
a mixture of natural polymers, specifically chitosan and sodium alginate
Implementation Method 6
accelerated wound healing
Implementation Method 7
biocompatible and biodegradable
Data Source
AI summary
A tissue adhesive for contacting a tissue site, the tissue adhesive comprising: a mixture of natural polymers; and an activating agent enhancing the adhesive properties of the mixture of natural polymers. And a tissue adhesive for contacting a tissue site, the tissue adhesive comprising: a mixture of natural polymers; and an aqueous solution of a water soluble starch or a water soluble starch derivative which forms a gel with the addition of the mixture of natural polymers.