Needle-Implanted Cryopreserved Tissue Delivery
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Solution Overview
Problem
Current preserved animal tissue products face limitations in storage and use due to inefficiencies in preservation and delivery methods, restricting their effectiveness and convenience in medical applications.
Innovation Solution
A preserved tissue product is developed, featuring a sheet of animal tissue, such as human amniotic tissue, packed within a needle device lumen, impregnated with a vitrified cryopreservation medium, allowing for convenient storage and direct delivery to patients by thawing and ejecting the tissue through the needle cannula.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of operation
If animal tissue is preserved using conventional cryopreservation media and storage methods, then tissue preservation is achieved, but storage convenience and delivery efficiency are limited
Solution Approach 1:
The tissue sample is placed inside an inner container, which is then placed inside an outer container. Both containers are filled with cryopreservation medium. The nested structure allows the tissue to be preserved in a compact, self-contained unit that is convenient for storage and transport while maintaining effective cryopreservation conditions.
Solution Approach 2:
The tissue is impregnated with cryopreservation medium and frozen in a vitrified state before storage. This preliminary preparation allows the tissue to be stored in a stable, space-efficient form and delivered ready-for-use, eliminating the need for complex preservation infrastructure at the point of delivery.
2Productivity
If tissue is stored in conventional preservation media, then tissue viability is maintained, but delivery time and efficiency are reduced
Solution Approach 1:
The tissue is prepared, impregnated with cryopreservation medium, and frozen in advance. This preliminary action allows the tissue to be stored ready-for-delivery and rapidly deployed when needed, significantly reducing processing time and improving delivery efficiency.
Solution Approach 2:
The cryopreservation medium is frozen in a vitrified state for storage, then rapidly thawed to liquid state for delivery. This phase transition enables compact storage and rapid deployment, transforming the tissue from a stable storage form to a ready-for-implantation form in minutes.
3Volume of stationary object
If conventional cryopreservation methods are used, then tissue preservation is achieved, but storage space efficiency is reduced
Solution Approach 1:
The inner container with tissue is nested inside an outer container, both filled with cryopreservation medium. This nested arrangement maximizes space efficiency while ensuring the tissue remains surrounded by protective medium throughout storage, maintaining preservation reliability.
Solution Approach 2:
The containers use flexible membranes that conform to the tissue and medium, eliminating excess space and allowing compact storage. The flexible packaging maintains intimate contact between the tissue and cryopreservation medium while minimizing overall volume.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This solution enables efficient storage and direct implantation of animal tissue, maintaining bioactive factors and cell viability, thereby enhancing the effectiveness and convenience of tissue delivery in medical treatments.
Implementation Method 1
an aqueous cryopreservation medium impregnating the sheet of animal tissue
Implementation Method 2
thawing the preserved tissue product to liquefy the vitrified cryopreservation medium
Data Source
AI summary
Disclosed are products having animal tissue packed within the lumen of a device such as a needle cannula and being therein impregnated with a cryopreservation medium. The needle cannula or other device can be received in a capsule and/or other container, which in some forms can contain additional amounts of the cryopreservation medium occurring external of the lumen. Methods of use of the products are also described and can include ejecting the animal tissue from the lumen of device using pressurized liquid passed through the lumen, potentially to deliver the animal tissue directly into a patient. Methods of manufacture of the products are also described.