Needle Delivery Device for Rapid Bolus Injection
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Solution Overview
Problem
Existing injection devices are complex, cumbersome, and expensive, and struggle to deliver large volumes of drugs rapidly as bolus doses, which is necessary for achieving correct plasma drug concentrations, while also avoiding tissue irritation and damage.
Innovation Solution
A needle delivery device with moveable skin pinching members, sensing mechanisms, and a drive mechanism to insert and retract a needle parallel to the skin, allowing for rapid injection of large volumes by gradually withdrawing the needle through a longitudinally pinched skin fold, enabling precise delivery of pharmaceutical compositions.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Quantity of substance
If body-worn devices are used to deliver large volumes of drugs, then the drug can be injected over an extended period of time, but the injection time is extended to several hours which is too slow for bolus doses
Solution Approach 1:
The device dynamically adjusts the needle insertion depth and skin pinching level during the injection process. The needle can be inserted to varying depths and the skin fold can be pinched to different levels, allowing the system to optimize injection parameters in real-time to deliver large volumes rapidly while maintaining safety and tissue integrity
Solution Approach 2:
The injection process is segmented into multiple phases: skin pinching, needle insertion at controlled depths, drug delivery, and needle withdrawal. This segmentation allows each phase to be optimized independently, enabling rapid bolus delivery while managing the overall injection time through controlled multi-stage progression
2Object-affected harmful factors
If the needle path extends parallel to the skin surface, then the needle can be inserted at shallow angles to avoid tissue damage, but the insertion depth must be precisely controlled to ensure proper drug delivery
Solution Approach 1:
The device incorporates sensing means that provide real-time feedback on needle position, skin pinching level, and tissue engagement. This feedback enables the control system to automatically adjust needle insertion depth and maintain parallel trajectories, ensuring precise drug delivery while minimizing tissue damage through continuous monitoring and adjustment
3Measurement precision
If multiple sensing means are used to detect pinching along the length of the skin fold, then the pinching uniformity can be verified, but the device complexity increases
Solution Approach 1:
The sensing system is segmented into multiple independent sensing elements distributed along the needle path. Each sensing element detects pinching conditions at its specific location, and the results are integrated to verify overall pinching uniformity. This segmentation allows distributed measurement with reduced complexity at each individual sensing point
Data Source
Figure 1A~1B
Figure 2
Figure 3A~3C
AI summary
The invention relates to a needle delivery device comprising a device body; one or more skin pinching members attached to the device body, the skin pinching members being moveable to pinch a longitudinal fold of skin of a patient. The device also comprises a drive mechanism configured to drive a needle out of the device body and along a needle path into the longitudinal fold of skin pinched between the pinching members, and subsequently withdraw the needle, the needle path extending substantially parallel to the surface of the patient.