Nefazodone-Risperidone Combination Therapy for Suicide Ideation
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Solution Overview
Problem
Suicide rates have been increasing, with significant emotional, physical, and economic impacts, and existing treatments for psychiatric disorders such as suicidal ideation and major depressive disorder are inadequate in reducing suicide ideation and impulsivity.
Innovation Solution
A combination therapy using nefazodone and risperidone, administered in a unit dose with pharmaceutically acceptable excipients, targets both suicide ideation and impulsivity to reduce the willingness to act on suicidal thoughts.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If existing treatments for psychiatric disorders are used, then treatment coverage is provided, but effectiveness in reducing suicide ideation and impulsivity is inadequate
Solution Approach 1:
The patent combines nefazodone (an antidepressant) and risperidone (an antipsychotic) into a single fixed-dose combination tablet. This merging of two separate medications addresses the inadequacy of existing treatments by providing synergistic effects that reduce both suicide ideation and impulsivity, thereby improving treatment reliability and efficacy simultaneously.
2Adaptability or versatility
If multiple separate medications are administered, then comprehensive treatment coverage is achieved, but treatment complexity increases
Solution Approach 1:
By consolidating nefazodone and risperidone into a single fixed-dose combination tablet, the patent reduces treatment regimen complexity while maintaining comprehensive treatment coverage. Patients take one tablet instead of multiple separate medications, simplifying adherence while achieving the therapeutic benefits of both drugs.
Solution Approach 2:
The fixed-dose combination tablet serves multiple functions simultaneously: it provides antidepressant effects from nefazodone, antipsychotic effects from risperidone, and simplifies the treatment regimen. This multi-functionality allows a single medication to address multiple aspects of psychiatric disorders including suicide ideation and impulsivity.
Data Source
AI summary
The present invention provides for a method of treating a person suffering from a psychiatric disorder that includes administration of a pharmaceutically effective amount of (i) nefazodone, or a pharmaceutically acceptable salt thereof, and (ii) risperidone. Also provided is a unit dose that includes (i) nefazodone, or a pharmaceutically acceptable salt thereof, (ii) risperidone, and (iii) one or more pharmaceutically acceptable excipients. Also provided is a therapeutic package that includes (a) the unit doses, (b) a finished pharmaceutical container that contains the unit doses, (c) printed indicia, and (d) optionally an outside container containing the finished pharmaceutical container and the printed indicia.