Negative-Pressure Wound Therapy Using Peroxy Pyruvic Instillation

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Solution Overview

Problem

Existing wound treatment technologies lack effective systems and methods to combat healthcare-associated infections (HAIs), biofilms, and planktonic microbes using negative-pressure and instillation therapy, particularly against resistant pathogens like MRSA and C. difficile spores.

Innovation Solution

The use of antimicrobial solutions comprising peroxy α-keto carboxylic acids, such as peroxy pyruvic acid, in conjunction with negative-pressure and instillation therapy systems, including a dressing to deliver the solution and control pressure modes to enhance wound healing.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Productivity

If negative-pressure therapy is applied to promote tissue growth and granulation, then wound healing is accelerated, but the risk of introducing and spreading infections (HAIs, biofilms, planktonic microbes) increases due to the pressure differential

Engineering Contradiction:

Improvewound healing speedVSAvoidinfection risk

Core Design Contradiction:

ProductivityVSObject-affected harmful factors

Solution Approach 1:

The system applies antimicrobial solution to the wound bed before negative pressure is applied, creating a protective antimicrobial environment in advance. This preliminary action prevents pathogens from being drawn into the wound during negative pressure therapy, addressing the infection risk before it can manifest

Inventive Principle:

Principle #9Preliminary anti-action

Solution Approach 2:

The system continuously applies negative pressure throughout the treatment period while maintaining the antimicrobial solution in contact with the wound bed. This continuous application ensures that the beneficial tissue growth effects are sustained while the antimicrobial protection remains active, preventing infection throughout the entire healing process

Inventive Principle:

Principle #20Continuity of useful action

2Object-affected harmful factors

If instillation therapy is used to cleanse the wound bed and remove contaminants, then bacterial burden is decreased, but treatment time and complexity increase

Engineering Contradiction:

Improvebacterial burdenVSAvoidtreatment duration

Core Design Contradiction:

Object-affected harmful factorsVSLoss of time

Solution Approach 1:

The system combines instillation therapy with negative-pressure therapy into a single integrated treatment process. The antimicrobial solution is instilled into the wound bed, then negative pressure is applied to simultaneously draw out contaminants and maintain the antimicrobial environment, achieving both cleansing and accelerated healing in one unified process rather than separate treatments

Inventive Principle:

Principle #5Merging (Combining)

Solution Approach 2:

The antimicrobial solution serves multiple functions: it cleanses the wound bed by removing contaminants, prevents new infections by killing introduced pathogens, and promotes tissue growth. This multi-functionality reduces the need for multiple separate treatments, thereby reducing overall treatment time despite the added efficacy

Inventive Principle:

Principle #6Universality (Multi-functionality)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The system effectively mitigates HAIs, biofilms, and planktonic microbes, promoting tissue granulation and reducing healing times by using peroxy pyruvic acid in negative-pressure and instillation therapy.

Implementation Method 1

a negative-pressure source fluidly coupled to the dressing and adapted to provide negative pressure to the therapeutic environment after delivery of the antimicrobial fluid

Methodology Applied

Scientific EffectNegative pressure: Pressure Gradient

Implementation Method 2

antimicrobial solutions comprising peroxy pyruvic acid have demonstrated unique safety and efficacy properties that can mitigate or treat the increasing threat of HIAs, including the most resistant pathogens such as methicillin resistant Staphylococcus aureus (MRSA), CRE and C. difficile spores

Methodology Applied

Scientific EffectAntimicrobial action of peroxy α-keto carboxylic acids: Oxidation

Data Source

PatentUS12521481B2System and methods for the treatment of wounds with negative pressure and instillation of peroxide pyruvic acid

Publication Date: 2026.01.13 SOLVENTUM INTELLECTUAL PROPERTIES CO

AI summary

A system and method for treating a tissue site is described having a dressing adapted to contact the tissue site and provide a fluid seal, and a solution source fluidly coupled to the dressing and adapted to deliver an antimicrobial solution comprising a peroxy α-keto carboxylic acid, such as peroxy pyruvic acid, to the dressing. The system may include a negative-pressure source fluidly coupled to the dressing and adapted to provide negative pressure to the dressing after delivery of the antimicrobial fluid to the dressing.