Nematode Cancer Test System Quality Control
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Solution Overview
Problem
The existing cancer test using nematodes lacks effective quality control, as the reliability of the test results is heavily dependent on the individual skill of the tester and environmental conditions, leading to inconsistent nematode quality and test outcomes.
Innovation Solution
A cancer test system that includes a quality information acquisition section, a first taxis information generation section, a quality determination section, a test information acquisition section, a second taxis information generation section, and a cancer test determination section to assess nematode quality and determine cancer presence based on taxis actions, ensuring consistent and reliable results.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Adaptability or versatility
If manual procedures are used for preparing taxis plates and assessing nematode quality, then flexibility and adaptability are maintained, but reliability and consistency of test results deteriorate due to dependence on individual tester skill
Solution Approach 1:
The patent creates a standardized protocol that can be copied and replicated across different laboratories and testers. The detailed step-by-step procedures for plate preparation, nematode handling, and quality assessment can be uniformly implemented, ensuring that the same operations yield consistent results regardless of who performs them, thereby improving reliability while maintaining the adaptability of the manual process.
2Stability of the object's composition
If environmental conditions and culture parameters are tightly controlled, then nematode quality should improve, but in practice quality control still deteriorates without standardized assessment procedures
Solution Approach 1:
The patent implements a feedback mechanism through standardized quality assessment procedures. By establishing clear criteria for evaluating nematode quality (such as counting nematodes on taxis plates, assessing their distribution patterns, and determining attraction/repulsion responses), the system provides feedback on whether environmental controls and culture conditions are producing the desired nematode quality, allowing for continuous improvement and consistent quality control.
Solution Approach 2:
The patent standardizes specific parameters including the composition of the taxis plate medium (agar concentration, nutrient components), environmental conditions (temperature, humidity), and assessment metrics (number of nematodes counted, distribution patterns). By controlling and standardizing these parameters, the patent transforms the variable quality control process into a reliable, repeatable procedure that consistently produces high-quality nematode assessments.
3Reliability
If detailed manual procedures are followed for each step, then quality control should improve, but productivity and efficiency deteriorate due to time-consuming operations
Solution Approach 1:
The patent performs preliminary actions by preparing standardized taxis plates with pre-defined medium compositions and markings before nematode assessment begins. The protocol establishes predetermined counting zones and reference points on the plates, so that during the actual assessment, testers only need to observe and record within these pre-established parameters, significantly reducing the time required per test while maintaining quality control.
Solution Approach 2:
The patent implements a practical assessment approach by counting a specific number of nematodes (e.g., 50-100 nematodes per plate) rather than attempting to count or analyze every single nematode present. This partial action approach provides sufficient statistical reliability for quality determination while dramatically improving productivity compared to exhaustive counting methods.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The system efficiently performs quality determination of nematodes, enhancing the reliability of cancer test results by standardizing the assessment of nematode quality and cancer detection through automated analysis of taxis actions.
Implementation Method 1
A nematode shows positive chemotaxis to urine of a cancer patient and negative chemotaxis to urine of a healthy subject
Data Source
AI summary
In order to determine, in a cancer test using nematodes, whether or not the nematodes used in the cancer test are adequate, the present invention is characterized in that after a plate on which a urine from a subject and the nematode are set is placed, a cancer test apparatus performs imaging for quality assay of the nematode during the initial two minutes; an analysis apparatus determines a quality of the nematode using the imaging result; after taxis of the nematode is completed, the cancer test apparatus performs imaging for cancer test assay by the nematode; and the analysis apparatus determines the presence or absence of a cancer in the subject using the imaging result.