Deep Learning Prediction Models for Neonatal IVH Risk

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Solution Overview

Problem

Existing technologies fail to effectively diagnose and address the challenges of intraventricular hemorrhage and early death in very low birth weight infants, particularly in the immediate postnatal period, with limited treatment options and a high risk of poor prognosis.

Innovation Solution

A deep learning-based apparatus and method for supporting diagnosis of intraventricular hemorrhage and early death in very low birth weight infants, which utilizes deep learning to diagnose the possibility of intraventricular hemorrhage and early death within a week in very low birth weight infants, which utilizes a data collection, preprocessing, and prediction model learning, and diagnosis apparatus for predicting and outputting the diagnosis of intraventricular hemorrhage and early death within a week in very low birth weight infants.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Measurement precision

If traditional statistical methods such as logistic regression are used to identify risk factors in clinical studies of IVH, then the analysis can be conducted with available data, but the diagnostic precision and predictive accuracy for IVH are insufficient

Engineering Contradiction:
Improvediagnostic precisionVSAvoidsystem complexity
Core Design Contradiction:
Measurement precisionVSDevice complexity

Solution Approach 1:

The patent replaces traditional statistical methods (logistic regression) with deep learning-based AI systems. Specifically, it employs convolutional neural networks (CNNs) for imaging data analysis and recurrent neural networks (RNNs) for temporal clinical data processing, achieving superior diagnostic precision in predicting IVH and early death in VLBWIs while automating the complex analysis of multiple risk factors

Inventive Principle:
Principle #28Mechanics substitution (Replace mechanical system)

Solution Approach 2:

The patent integrates multiple data types and modalities into a unified predictive system. It combines imaging data (brain ultrasound, MRI), clinical data (demographics, maternal history, delivery information), and laboratory data into a composite deep learning model that leverages the strengths of each data type to improve overall diagnostic accuracy

Inventive Principle:
Principle #40Composite materials

2Reliability

If deep learning technology is applied to predict IVH and early death in very low birth weight infants, then diagnostic accuracy and early prediction capability are improved, but the complexity of the prediction system increases

Engineering Contradiction:
Improveprediction reliabilityVSAvoidprediction system complexity
Core Design Contradiction:
ReliabilityVSDevice complexity

Solution Approach 1:

The patent divides the prediction system into multiple specialized models: a prenatal prediction model using maternal and fetal data, a perinatal prediction model using delivery and immediate newborn data, and a postnatal prediction model using ongoing clinical monitoring data. Each model is trained on specific time-point data and can be independently deployed, reducing overall system complexity while maintaining high prediction reliability

Inventive Principle:
Principle #1Segmentation

Solution Approach 2:

The patent introduces a data preprocessing and feature extraction layer that acts as an intermediary between raw medical data and the deep learning prediction models. This layer standardizes diverse data formats, extracts relevant features, and prepares inputs in a unified format, simplifying the interface between data sources and prediction algorithms

Inventive Principle:
Principle #24Intermediary (Mediator)

3Measurement precision

If comprehensive data collection including demographic information, maternal information, delivery information, neonatal information, disease information, and vital signs is performed, then the predictive model accuracy is improved, but the data processing time and computational resources increase

Engineering Contradiction:
Improveprediction accuracyVSAvoiddata processing time
Core Design Contradiction:
Measurement precisionVSLoss of time

Solution Approach 1:

The patent performs data preprocessing, cleaning, and feature extraction in advance during the data collection phase. It creates standardized data structures and pre-computes derived features (such as gestational age calculations, Apgar score computations) before the actual prediction is needed, significantly reducing processing time during critical clinical decision-making moments

Inventive Principle:
Principle #10Preliminary action

Solution Approach 2:

The patent implements a dynamic prediction system that can adapt its data requirements based on the clinical context and prediction stage. The model can operate with different levels of data completeness, allowing for rapid preliminary assessments with available data and progressively improving accuracy as additional data becomes available, rather than requiring all data to be processed simultaneously

Inventive Principle:
Principle #15Dynamics

Data Source

PatentUS20250391564A1Apparatus and method for supporting diagnosis of intraventricular hemorrhage and early death within a week in very low birth weight infants based on deep learning
Publication Date: 2025.12.25 CHONBUK NAT UNIV HOSPITAL
  • US20250391564A1 patent drawing
  • US20250391564A1 patent drawing
  • US20250391564A1 patent drawing

AI summary

A method for supporting diagnosis of intraventricular hemorrhage and early death within a week in very low birth weight infants based on deep learning includes a data collection step, a data preprocessing step, a learning step of training a prenatal prediction model, training a birth prediction model and training a postnatal prediction model, and a diagnosis step of, when a diagnosis target and diagnosis time are determined, selecting one prediction model based on the diagnosis time, analyzing medical information of the diagnosis target through the selected prediction model, and predicting and outputting the intraventricular hemorrhage diagnosis result.