Sutureless Nerve Coupling Apparatus for Swelling Accommodation
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Solution Overview
Problem
Current nerve coaptation methods, including microsutures and sleeve-based devices, face limitations such as long recovery times and limited nerve functionality due to nerve compression from swelling, which hinders effective regeneration.
Innovation Solution
A microsuture-less nerve coaptation apparatus featuring relatively-movable coupling members that inhibit nerve compression by allowing for swelling, comprising biodegradable and non-neurotoxic polymers with expandable joints and epineurium pins to securely connect and align nerve segments, while pharmaceutical agents are delivered to facilitate repair.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Stability of the object's composition
If a rigid sleeve is used to house nerve segments, then nerve alignment is improved, but nerve compression occurs when swelling happens
Solution Approach 1:
The coupling members are designed to be movable relative to each other, allowing the structure to dynamically adjust to nerve swelling while maintaining alignment. The movable connection enables the apparatus to accommodate volume changes without creating compressive forces.
Solution Approach 2:
The coupling members function as flexible connection elements that can deform and move to accommodate nerve swelling. This flexibility allows the structure to maintain nerve alignment while preventing compression by adapting to changes in nerve volume.
2Reliability
If microsutures are used to connect nerve segments, then nerve coaptation is achieved, but recovery time is prolonged and functionality is limited
Solution Approach 1:
The invention removes the suture material from the nerve repair process entirely. By using a sutureless coupling apparatus, it eliminates the need for foreign material that can cause inflammation and delay healing, thereby reducing recovery time while maintaining reliable nerve coaptation.
Solution Approach 2:
The coupling members serve as an intermediary structure that brings nerve segments into proper alignment and maintains coaptation without requiring sutures. This intermediary device facilitates nerve regeneration by providing mechanical support and alignment while allowing natural healing processes to occur without suture-related complications.
3Productivity
If pharmaceutical agents are incorporated into the sleeve, then axonal growth is promoted, but device complexity increases
Solution Approach 1:
Pharmaceutical agents are incorporated locally into the coupling members or delivered directly to the nerve segments at the site of injury. This localized delivery promotes axonal growth where needed without requiring complex device structures, as the pharmacological enhancement is concentrated at the critical interface between nerve segments.
Data Source
AI summary
The present disclosure is directed to the use of fusogenic compounds such as polyethylene glycol (PEG) in combination with antioxidants, calcium-containing and calcium-free solutions for treating damaged nerves, such as for reconnecting severed nerves.