Transdermal NES-Testosterone Gel for Sperm Suppression Balance
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Solution Overview
Problem
Existing male contraceptive methods are limited, inconvenient, and often result in undesirable side effects, with a need for a safe, effective, and reversible method that maintains testosterone levels within the normal range while reducing sperm count.
Innovation Solution
A transdermal composition comprising 16-methylene-17α-acetoxy-19-norpregn-4-ene-3,20-dione (NES) and testosterone (T) in specific ratios, applied as a hydroalcoholic gel, to suppress gonadotropins and sperm concentration without significant side effects.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If high doses of testosterone are used to suppress sperm production, then contraceptive effectiveness is improved, but testosterone levels become excessively high causing side effects
Solution Approach 1:
The patent changes the parameter of testosterone dosage by using low-dose testosterone (62.5-100 mg) in combination with progestin, rather than high doses alone. This parameter adjustment allows suppression of sperm production while maintaining testosterone levels within the normal physiological range, avoiding excessive side effects.
Solution Approach 2:
The patent creates a composite hormonal formulation combining testosterone with progestin (NES) in specific ratios. This composite approach leverages the synergistic effect of both hormones to achieve effective sperm suppression while the progestin component helps regulate testosterone levels and reduce androgenic side effects.
2Ease of operation
If testosterone replacement therapy is used to treat hypogonadism, then libido and sexual function are improved, but sperm production is inhibited
Solution Approach 1:
The patent adjusts the parameter of testosterone dosage to low-dose ranges (62.5-100 mg) that are sufficient to treat hypogonadism symptoms but not high enough to completely inhibit sperm production. This parameter optimization allows simultaneous improvement of sexual function and maintenance of fertility potential.
Solution Approach 2:
The patent creates a dynamic hormonal balance by combining testosterone with progestin, where the progestin component modulates the androgenic effects. This dynamic interaction allows the formulation to treat hypogonadism symptoms while maintaining reversible suppression of spermatogenesis, enabling future fertility restoration.
3Reliability
If progestin is added to testosterone to suppress gonadotropins, then sperm concentration is reduced, but the formulation complexity increases
Solution Approach 1:
The patent merges testosterone and progestin into a single transdermal gel formulation, combining two hormonal components in one application. This merging simplifies the delivery system compared to separate injections or multiple applications, while achieving effective gonadotropin suppression and sperm concentration reduction.
Solution Approach 2:
The patent optimizes the parameter ratios of testosterone to progestin in the formulation, using specific concentrations (e.g., 62.5-100 mg testosterone with corresponding progestin amounts). This parameter optimization ensures effective sperm suppression while maintaining formulation stability and ease of application.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The composition effectively suppresses sperm concentration while maintaining testosterone levels within the normal range, with minimal side effects, offering a convenient and reversible contraceptive option.
Implementation Method 1
transdermal composition comprising 16-methylene-17α-acetoxy-19-norpregn-4-ene-3,20-dione... testosterone... applied as a hydroalcoholic gel
Data Source
AI summary
The present disclosure relates to a specific combination of a progestin and testosterone in a transdermal composition and usage thereof in a method for ensuring male contraception with more efficacy and less side effects.