Nested Capsule Cannabinoid Formulations for Controlled Release
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Solution Overview
Problem
Current pharmaceutical and dietary supplement compositions face challenges in delivering cannabinoids effectively, particularly in controlling the release of active ingredients in the gastrointestinal tract and maintaining stability and bioavailability.
Innovation Solution
The development of pharmaceutical and dietary supplement compositions featuring spray-dried particles of cannabinoids encapsulated in a coating material, such as hydroxypropyl methylcellulose, which are further encapsulated in capsules with controlled release coatings, allowing for precise dosing and enhanced bioavailability.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If cannabinoids are delivered in traditional pharmaceutical compositions, then the basic delivery function is achieved, but the release control in the gastrointestinal tract is insufficient and bioavailability is reduced
Solution Approach 1:
The pharmaceutical composition is segmented into multiple functional layers: an inner capsule containing spray-dried cannabinoid particles with a first coating material, and an outer capsule containing a second coating material with different dissolution characteristics. This segmentation allows each layer to control release at different stages of gastrointestinal transit, achieving precise temporal and spatial release control while maintaining dosing accuracy.
Solution Approach 2:
The formulation employs a nested capsule structure where an inner capsule is placed inside an outer capsule. The inner capsule contains spray-dried particles with one coating material, while the outer capsule contains a different coating material. This nested arrangement enables sequential release mechanisms where the inner capsule releases cannabinoids at a specific gastrointestinal location, followed by the outer capsule, thereby achieving precise release control without compromising dosing precision.
2Stability of the object's composition
If traditional encapsulation methods are used, then basic protection is provided, but stability and bioavailability of cannabinoids are not optimized
Solution Approach 1:
Different regions of the formulation have specialized properties tailored to specific functions: the spray-dried particles have a first coating material optimized for initial protection and controlled dissolution, while the outer capsule contains a second coating material with different dissolution characteristics for extended protection. This local quality differentiation maximizes cannabinoid stability at each stage of gastrointestinal transit while the modular nature of the formulation keeps manufacturing complexity manageable.
Solution Approach 2:
The formulation uses composite materials consisting of multiple coating materials with different properties. The inner capsule employs a first coating material that provides initial protection and controlled release, while the outer capsule uses a second coating material with different dissolution characteristics. This composite approach enhances overall cannabinoid stability and bioavailability without requiring overly complex formulation structures, as each material layer performs a specific protective function.
3Ease of operation
If single-layer encapsulation is used, then the formulation is simple, but controlled release at different gastrointestinal locations is not achieved
Solution Approach 1:
The formulation employs dynamic release characteristics through the use of two different coating materials with distinct dissolution properties. The inner capsule's first coating material dissolves at a specific gastrointestinal location, enabling release at that site, while the outer capsule's second coating material dissolves at a different location or time, providing sequential release. This dynamic approach achieves precise spatial and temporal release control while maintaining a relatively simple nested capsule structure that is straightforward to manufacture.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This approach enables controlled release of cannabinoids in the gastrointestinal tract, improving bioavailability and stability, and maintaining therapeutic efficacy over time.
Implementation Method 1
The spray drying process can comprise: atomizing liquid droplets comprising the active ingredient or the pharmaceutically acceptable salt thereof and the coating material, drying the droplets to form particles, and recovering the particles.
Implementation Method 2
The capsule coating can at least partially control active ingredient release. In some embodiments, the capsule coating can comprise an enteric coating, a time release coating, a pH dependent coating, a delayed release coating, an extended-release coating, or a combination thereof.
Data Source
AI summary
Provided herein are pharmaceutical or dietary supplement compositions, kits comprising pharmaceutical or dietary supplement compositions, methods of treating and preventing disease, and methods of making compositions and kits described herein. The pharmaceutical or dietary supplement composition compositions described herein can be administered orally. The pharmaceutical or dietary supplement compositions can be administered by a capsule described herein.