Nested Nanoparticles for Coordinated Drug Delivery

Resolve Bottlenecks,
Find Innovative SolutionsGenerate Solutions

Solution Overview

Problem

Current combination chemotherapy regimens for cancer and other diseases face challenges due to pharmacokinetic limitations, such as short circulation half-lives and non-specific accumulation in healthy tissues, which hinder the synergistic effects of drug combinations delivered in a time-staggered fashion, as conventional drug formulations have disparate pharmacokinetic parameters and routes of administration that do not adhere to strict time constraints necessary for therapeutic crosstalk between synergistic agents.

Innovation Solution

A particle composition comprising a charged core element and a cyclodextrin coating with opposing charges, allowing for the sequential and timed release of therapeutic or imaging agents, with the cyclodextrin layer providing stability and controlling the release kinetics, enabling precise delivery of combinations of active agents to tumors.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If conventional drug formulations are used for combination chemotherapy, then multiple drugs can be administered, but the pharmacokinetic parameters (short circulation half-lives, disparate half-lives) prevent strict time constraints from being met, resulting in non-specific accumulation in healthy tissues and insufficient bioavailability in tumors

Engineering Contradiction:

Improvetime constraint adherenceVSAvoiddrug delivery coordination

Core Design Contradiction:

ReliabilityVSEase of operation

Solution Approach 1:

The patent combines multiple drugs with different pharmacokinetic properties into a single nanoparticle delivery system. The core nanoparticle contains one drug while the cyclodextrin coating contains another drug, allowing both drugs to be delivered simultaneously with coordinated release kinetics, thereby meeting strict time constraints for therapeutic crosstalk

Inventive Principle:

Principle #5Merging (Combining)

Solution Approach 2:

The patent employs a nested structure where one drug is embedded within the core nanoparticle and another drug is incorporated into the cyclodextrin coating layer. This nested arrangement enables sequential release where the coating drug releases first followed by the core drug, achieving the desired time-staggered delivery without requiring separate administration

Inventive Principle:

Principle #7Nested doll (Nesting)

2Reliability

If drugs are delivered in a time-staggered fashion to enhance synergistic effects, then therapeutic crosstalk between agents can be achieved, but conventional formulations have disparate pharmacokinetic parameters that preclude adherence to strict time constraints

Engineering Contradiction:

Improvesynergistic effect achievementVSAvoidcirculation half-life

Core Design Contradiction:

ReliabilityVSDuration of action of moving object

Solution Approach 1:

The patent modifies the physical and chemical parameters of drug delivery by incorporating drugs into a nanoparticle system with controlled release kinetics. The nanoparticle structure alters the circulation half-life and release profile of both drugs, enabling synchronized delivery that maintains therapeutic concentrations within the required time window for synergistic effects

Inventive Principle:

Principle #35Parameter changes

3Adaptability or versatility

If conventional drug formulations are used, then drugs can be administered through different routes, but the disparate pharmacokinetic parameters and distinct excipients result in non-specific accumulation in healthy tissues and insufficient bioavailability in tumors

Engineering Contradiction:

Improveroute of administrationVSAvoidnon-specific accumulation

Core Design Contradiction:

Adaptability or versatilityVSObject-affected harmful factors

Solution Approach 1:

The patent creates a universal nanoparticle delivery platform that can accommodate multiple drugs and be administered through a single route (intravenous injection). This multi-functional system addresses the targeting and release requirements for both drugs simultaneously, reducing non-specific accumulation in healthy tissues while improving tumor bioavailability

Inventive Principle:

Principle #6Universality (Multi-functionality)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

This approach enhances the synergistic effects of drug combinations by ensuring sequential and timed delivery, improving bioavailability and reducing adverse effects on healthy tissues, thereby achieving more effective treatment outcomes for cancer and other diseases.

Implementation Method 1

a charged core element and a first active agent embedded in, or conjugated to, the core element; and (ii) a cyclodextrin coating, surrounding the core element, said coating having the opposite charge of the core element

Methodology Applied

Scientific EffectElectrostatic interaction: Electrostatics

Data Source

PatentUS10076509B2Nested particles and the use thereof for coordinated delvery of active agents

Publication Date: 2018.09.18 BOARD OF RGT THE UNIV OF TEXAS SYST

AI summary

Methods and compositions regarding nested nanoparticles comprising polymer nanoparticles encased in a cyclodextrin shell to facilitate sequence-specific drug release.