Nested Woven Shells for Cerebral Aneurysm Occlusion

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Solution Overview

Problem

Current treatments for cerebral aneurysms, such as stents and vaso-occlusive coils, face challenges including limited effectiveness in wide-necked aneurysms, risk of migration, and difficulty in positioning defect spanning portions due to poor flexibility and rotational capability, necessitating improved devices for minimally invasive, long-term blood flow blockage without deformation or dislocation.

Innovation Solution

Intrasaccular occlusive devices with a permeable shell formed from woven or braided mesh, comprising inner and outer layers with different braid angles and filament diameters, allowing for controlled deployment and expansion to anchor within the aneurysm, promoting thrombosis and clotting while minimizing pressure on the aneurysm dome.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If current stents and vaso-occlusive coils are used to treat cerebral aneurysms, then blood flow blockage is achieved, but the devices suffer from limited effectiveness in wide-necked aneurysms, risk of migration, and difficulty in positioning

Engineering Contradiction:

Improveeffectiveness of blood flow blockageVSAvoiddifficulty in positioning defect spanning portions

Core Design Contradiction:

ReliabilityVSEase of operation

Solution Approach 1:

The device is divided into multiple segments including a defect spanning portion and an aneurysm filling portion, allowing independent positioning and function optimization. The defect spanning portion can be positioned across the aneurysm neck while the aneurysm filling portion occupies the aneurysm sac, resolving the positioning difficulty through functional segmentation.

Inventive Principle:

Principle #1Segmentation

Solution Approach 2:

The intrasaccular occlusive device is nested within the stent structure, with the defect spanning portion extending through the stent struts. This nesting allows the occlusive device to be supported by the stent framework while achieving independent positioning within the aneurysm sac, overcoming the limitation of traditional single-structure devices.

Inventive Principle:

Principle #7Nested doll (Nesting)

2Ease of operation

If stents are made with reduced density to fit through microcatheters, then delivery is facilitated, but when expanded there is only a small amount of stent structure bridging the aneurysm neck

Engineering Contradiction:

Improvedeliverability through microcatheterVSAvoidamount of stent structure bridging aneurysm neck

Core Design Contradiction:

Ease of operationVSReliability

Solution Approach 1:

Inventive Principle:

Principle #7Nested doll (Nesting)

Solution Approach 2:

The device combines a stent structure with an intrasaccular occlusive device made of different materials and structural properties. The stent provides structural support and scaffolding while the occlusive device provides flow diversion and occlusion, creating a composite system that overcomes the limitations of either component alone.

Inventive Principle:

Principle #40Composite materials

3Reliability

If surgical techniques are used to treat cerebral aneurysms, then effective treatment is achieved, but the procedures require major invasive surgery with extended periods under anesthesia and high risk to the patient

Engineering Contradiction:

Improveeffectiveness of aneurysm treatmentVSAvoidrisk to patient from invasive surgery

Core Design Contradiction:

ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The invention replaces the mechanical surgical clipping system with an endovascular delivery system. The device is delivered through a catheter inserted via peripheral access, eliminating the need for craniotomy and direct surgical exposure. This substitution of delivery mechanism reduces patient risk while maintaining treatment effectiveness.

Inventive Principle:

Principle #28Mechanics substitution (Replace mechanical system)

Solution Approach 2:

The stent-graft structure serves as an intermediary between the blood flow and the aneurysm sac. It provides a scaffold that supports the intrasaccular occlusive device and facilitates blood flow redirection away from the aneurysm, eliminating the need for direct surgical intervention while achieving aneurysm isolation.

Inventive Principle:

Principle #24Intermediary (Mediator)

4Reliability

If coils are used to fill an aneurysm cavity, then vaso-occlusion is achieved, but the coils suffer from poor packing density, compaction due to hydrodynamic pressure, and migration risk

Engineering Contradiction:

Improvevaso-occlusion effectivenessVSAvoidpacking density and resistance to compaction

Core Design Contradiction:

ReliabilityVSStability of the object's composition

Solution Approach 1:

The intrasaccular occlusive device uses a flexible mesh or fabric structure that can conform to the irregular shape of the aneurysm sac. This flexible shell structure provides distributed support and resistance to compaction forces, unlike rigid coil structures that compact and migrate under hydrodynamic pressure.

Inventive Principle:

Principle #30Flexible shells and thin films

Solution Approach 2:

Inventive Principle:

Principle #40Composite materials

Data Source

PatentUS12408925B2Multiple layer devices for treatment of vascular defects

Publication Date: 2025.09.09 MICROVENTION INC

AI summary

Devices and methods for treatment of a patient's vasculature are described. Embodiments may include a first permeable shell and a second permeable shell, where the second permeable shell sits within an interior cavity of the first permeable shell. The first and second permeable shells may each be made from a plurality of elongate filaments that are woven together to form a mesh. The mesh of the first permeable shell may have a larger mesh density and be softer than the mesh of the second permeable shell.