Networked Diffraction Apparatus for Automated Tissue Diagnosis
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Pathological analysis of in vitro tissue samples, such as biopsy samples, is labor-intensive, time-consuming, and relies heavily on subjective human assessment, leading to potential errors and inefficiencies.
Innovation Solution
A system comprising diffraction apparatus coupled to a computer database over a network, which collects and processes diffraction pattern data from in vitro samples using data analytics algorithms to provide a computer-aided diagnostic indicator for tissue samples or subjects.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Productivity
If human visual assessment is used for pathological analysis, then diagnostic capability is maintained, but labor intensity and time consumption increase
Solution Approach 1:
The patent replaces the mechanical/visual assessment system with an automated diffraction-based analytical system. X-ray diffraction apparatus objectively measures tissue structural properties, eliminating the need for human microscopists to visually assess tissue morphology, thereby increasing diagnostic speed while managing system complexity through automation
Solution Approach 2:
The patent creates digital copies of tissue samples through diffraction pattern acquisition. Instead of physically examining tissue sections, the system captures diffraction patterns that serve as digital representations of tissue structure, enabling rapid analysis without repeated physical handling of samples
2Reliability
If human visual assessment is used for pathological analysis, then diagnostic capability is maintained, but subjectivity and error rates increase
Solution Approach 1:
The patent substitutes subjective human visual assessment with objective automated measurement. The diffraction apparatus provides quantitative, reproducible measurements of tissue structural properties, eliminating variability in human judgment and improving diagnostic reliability
Solution Approach 2:
The system performs self-service analysis by automatically acquiring diffraction patterns, processing data through algorithms, and generating diagnostic indicators without requiring human intervention in the measurement and analysis process, thereby maintaining high reliability while simplifying operation
3Productivity
If traditional sample preparation methods are used, then tissue analysis is possible, but labor intensity and time consumption increase
Solution Approach 1:
The patent extracts the essential diagnostic information directly from tissue samples using diffraction, eliminating the need for complex traditional preparation steps such as staining, sectioning, and mounting. This extraction approach maintains diagnostic capability while significantly reducing preparation time and labor
Solution Approach 2:
The system performs preliminary structural characterization of tissues through diffraction measurement, which can be done on fresh or minimally processed samples. This preliminary action provides diagnostic information before traditional preparation is required, increasing throughput
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The system enables fast and accurate analysis of tissue samples by providing objective diagnostic indicators, reducing human error, and improving efficiency in pathological diagnosis.
Implementation Method 1
The system may comprise one or more diffraction apparatus operatively coupled to a computer database over a network, where the diffraction apparatus are configured to acquire small-angle x-ray scattering and/or wide-angle x-ray scattering data for an in vitro tissue sample
Implementation Method 2
the one or more diffraction apparatus are configured to perform small angle X-ray scattering (SAXS) measurements. In some embodiments, the one or more diffraction apparatus are configured to perform wide angle X-ray scattering (WAXS) measurements
Data Source
AI summary
Provided herein are diffractometer-based global diagnostic systems and uses thereof. The systems may comprise one or more diffraction apparatus operatively coupled to a computer database over a network. The one or more diffraction apparatus may be configured for transfer of data such as pathology lab image data, diffraction pattern data, subject data, or any combination thereof to the computer database over the network. The systems may further comprise one or more computer processors operatively coupled to the one or more diffraction apparatus, which computer processors may be configured to receive the data from the diffraction apparatus, transmit the data to the computer database, and process the data using a data analytics algorithm which may provide a computer-aided diagnostic indicator for the individual subject.