Neural Event Detection via Mechanomyography and Stimulus Timing

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Solution Overview

Problem

Current surgical diagnostic systems lack effective methods to accurately detect the presence of nerves during minimally invasive procedures, leading to potential nerve injury due to inadequate detection techniques.

Innovation Solution

A neural monitoring system utilizing a non-invasive mechanical sensor, stimulator, and processor that provides periodic stimuli and analyzes mechanomyography output signals using advanced filtering techniques and supervised learning algorithms to differentiate artificially-induced muscle responses from other movements, thereby indicating the presence of nerves.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Measurement precision

If traditional surgical diagnostic systems are used, then the detection method is simple, but the accuracy of nerve detection is insufficient leading to potential nerve injury

Engineering Contradiction:
Improveaccuracy of nerve detectionVSAvoidcomplexity of detection system
Core Design Contradiction:
Measurement precisionVSDevice complexity

Solution Approach 1:

The system segments the detection process into distinct functional modules: a stimulator module that delivers electrical stimuli, a sensor module that detects mechanical responses, and a processor module that analyzes signals. This segmentation allows each component to be optimized independently while maintaining overall system accuracy without excessive complexity

Inventive Principle:
Principle #1Segmentation

Solution Approach 2:

The patent introduces an intermediary mechanical sensor that detects muscle responses indirectly caused by nerve stimulation, rather than directly measuring neural activity. This intermediary approach enables accurate nerve detection while using simpler mechanical sensing technology instead of complex neural recording systems

Inventive Principle:
Principle #24Intermediary (Mediator)

2Ease of operation

If minimally invasive surgical techniques are used, then the surgical exposure is reduced, but the ability to detect and avoid nerves is compromised

Engineering Contradiction:
Improveminimally invasive procedure easeVSAvoidnerve detection capability
Core Design Contradiction:
Ease of operationVSMeasurement precision

Solution Approach 1:

The system replaces direct visual/mechanical inspection methods with electrical stimulation and mechanical sensing technology. The stimulator delivers electrical impulses that travel through nerves to muscles, and the mechanical sensor detects the resulting muscle contractions, providing accurate nerve location data without requiring surgical exposure

Inventive Principle:
Principle #28Mechanics substitution (Replace mechanical system)

Solution Approach 2:

The system uses the body's own neuromuscular system as part of the detection mechanism. By stimulating a nerve and detecting the muscle's natural mechanical response, the system leverages the body's inherent physiological pathways to provide detection information, eliminating the need for external complex imaging or exposure equipment

Inventive Principle:
Principle #25Self-service

3Reliability

If advanced filtering techniques and supervised learning algorithms are implemented, then false positives are reduced, but the processing complexity increases

Engineering Contradiction:
Improvereduction of false positivesVSAvoidsignal processing complexity
Core Design Contradiction:
ReliabilityVSDevice complexity

Solution Approach 1:

The system implements feedback mechanisms where the processor continuously analyzes mechanomyography signals, compares detected responses against expected patterns, and adjusts detection parameters accordingly. This feedback loop enables the system to learn from actual surgical conditions and reduce false positives while maintaining manageable processing complexity through adaptive rather than purely complex algorithms

Inventive Principle:
Principle #23Feedback

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The system enhances the accuracy of nerve detection, reduces false positives, and provides real-time indications to surgeons, minimizing the risk of nerve injury during surgical procedures.

Implementation Method 1

The mechanical sensor is configured to be placed in mechanical communication with the muscle and is operative to generate a mechanomyography output signal that corresponds to a sensed mechanical movement of the muscle.

Methodology Applied
Scientific EffectMechanomyography:

Implementation Method 2

The stimulator is configured to provide a periodic stimulus within the intracorporeal treatment area, where the periodic stimulus includes at least a first stimulus beginning at a first time (T1), and a second, consecutive stimulus beginning at a second time (T2).

Methodology Applied
Scientific EffectElectrical stimulation:

Data Source

PatentEP3801742B1Neural event detection
Publication Date: 2022.05.04 DEPUY SYNTHES PROD INC
  • EP3801742B1 patent drawingFigure 1
  • EP3801742B1 patent drawingFigure 2~3
  • EP3801742B1 patent drawingFigure 4

AI summary

A neural monitoring system for detecting an artificially-induced mechanical muscle response to a stimulus provided within an intracorporeal treatment area includes a mechanical sensor, a stimulator, and a processor. The processor is configured to provide a periodic stimulus via the stimulator, and monitor the output from the mechanical sensor in an expected response window that follows one stimulus, yet concludes before the application of the next, subsequent stimulus to determine if the stimulus induced a response of the muscle.