Neural Network Attribution for Diagnostic Interpretability

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Solution Overview

Problem

Medical professionals face challenges in interpreting the outputs of computer-aided diagnostic models, particularly neural networks, as it is unclear how these models attribute their outputs to the input images, making it difficult to explain their decisions and identify potential failures.

Innovation Solution

The development of diagnostic platforms that apply attribution methods, such as Integrated Gradients, to attribute the outputs of neural networks to their inputs, providing visualizations that highlight the contributing pixels and enabling better understanding and trust in the diagnostic process.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Measurement precision

If neural networks are used for computer-aided diagnostic processes, then diagnostic accuracy and efficiency are improved, but interpretability and explainability of the outputs deteriorate

Engineering Contradiction:
Improvediagnostic accuracyVSAvoidinterpretability of outputs
Core Design Contradiction:
Measurement precisionVSLoss of information

Solution Approach 1:

The patent introduces attribution methods as intermediary techniques that bridge the gap between the neural network's internal processing and human interpreters. These methods generate attribution maps that serve as mediators, translating the network's decision-making process into visual representations that medical professionals can understand and validate.

Inventive Principle:
Principle #24Intermediary (Mediator)

Solution Approach 2:

The patent employs visual attribution techniques that use color-coded representations to indicate the importance of different input features. By transforming abstract numerical attributions into intuitive visual displays with varying colors and intensities, the system makes the neural network's reasoning process visible and interpretable to human users.

Inventive Principle:
Principle #32Color changes

2Productivity

If complex neural networks are deployed for diagnostic tasks, then productivity and speed of diagnosis are improved, but reliability and trustworthiness deteriorate due to inability to explain decisions

Engineering Contradiction:
Improvespeed of diagnosisVSAvoidtrustworthiness of diagnostic model
Core Design Contradiction:
ProductivityVSReliability

Solution Approach 1:

The patent implements feedback mechanisms where attribution information is provided back to users alongside the diagnostic output. This feedback loop allows medical professionals to verify the network's reasoning, build trust in the system's decisions, and maintain reliability while benefiting from the speed of automated analysis.

Inventive Principle:
Principle #23Feedback

Solution Approach 2:

Attribution methods serve as intermediaries that translate the black-box neural network operations into interpretable forms, enabling users to verify and trust the system's decisions without sacrificing the speed and productivity benefits of automated diagnostic processing.

Inventive Principle:
Principle #24Intermediary (Mediator)

3Measurement precision

If neural networks process medical images to detect abnormalities, then detection capability is improved, but difficulty in identifying potential failures and latent variables increases

Engineering Contradiction:
Improvedetection capabilityVSAvoididentification of failures and latent variables
Core Design Contradiction:
Measurement precisionVSDifficulty of detecting and measuring

Solution Approach 1:

Attribution methods act as intermediaries that expose the neural network's internal reasoning process, allowing users to identify potential failures and latent variables by examining which input features most influenced the output. This transparency enables detection of problematic patterns without reducing detection capability.

Inventive Principle:
Principle #24Intermediary (Mediator)

Solution Approach 2:

Visual attribution techniques use color-coded displays to highlight important input features, making it easier to identify potential failures and latent variables by showing which regions of the medical image most influenced the diagnostic decision.

Inventive Principle:
Principle #32Color changes

Data Source

PatentUS11288800B1Attribution methodologies for neural networks designed for computer-aided diagnostic processes
Publication Date: 2022.03.29 VERILY LIFE SCIENCES LLC
  • US11288800B1 patent drawing
  • US11288800B1 patent drawing
  • US11288800B1 patent drawing

AI summary

Introduced here are diagnostic platforms able to attribute an output produced by a neural network to its input, as well as communicate the relationship between the output and input in a comprehensible manner. Neural networks are increasingly being used for critical tasks, such as detecting the presence/progression of medical conditions. Accordingly, the importance of explaining how these neural networks produce outputs has grown in importance. By explaining how outputs are produced by a neural network, a diagnostic platform can build trust with medical professionals responsible for interpreting the outputs, identify possible modes of neural network failure, and identify the latent variable(s) responsible for producing a given output.