Neuromapping Catheter for Renal Sympathetic Nerve Activity Evaluation
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Solution Overview
Problem
Current methods for treating refractory hypertension, such as percutaneous catheter renal sympathetic radiofrequency ablation, face challenges in preoperative and postoperative evaluation of nerve activity and surgical effectiveness, making it difficult to determine the need for repeat procedures.
Innovation Solution
A preoperative and postoperative neuromapping detection method using an electrode catheter system with an interventional catheter, pressure sensor, and data processing module to assess nerve activity by monitoring heart rate and blood pressure changes, allowing for evaluation of surgical efficacy and potential need for additional ablation.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If percutaneous catheter renal sympathetic radiofrequency ablation is performed to treat refractory hypertension, then blood pressure control is improved, but the ability to evaluate surgical effectiveness is worsened
Solution Approach 1:
The patent applies preliminary action by performing neuromapping detection before surgery to evaluate preoperative nerve activity degree, and after surgery to evaluate postoperative nerve activity degree. This allows the surgical effectiveness to be evaluated at different stages, providing baseline comparison and outcome assessment capabilities that were previously unavailable.
Solution Approach 2:
The patent implements feedback by using the neuromapping detection results to guide clinical decision-making. The preoperative assessment determines whether the patient is suitable for surgery, and the postoperative assessment determines whether additional ablation is needed, creating a closed-loop feedback system that continuously monitors and responds to treatment effectiveness.
2Measurement precision
If neuromapping detection is performed before and after surgery, then surgical effectiveness evaluation is improved, but the complexity of the detection system is worsened
Solution Approach 1:
The patent applies universality by designing a detection system that serves multiple functions: it assesses preoperative nerve activity to determine surgical candidacy, monitors intraoperative nerve activity during ablation, and evaluates postoperative nerve activity to determine the need for additional procedures. This multi-functional approach consolidates what would otherwise require separate detection systems into one unified platform.
Solution Approach 2:
The patent merges the detection of heart rate changes and blood pressure changes into a single integrated neuromapping detection system. By combining these physiological parameter measurements and analyzing them together to determine nerve activity degree, the system reduces overall complexity compared to using separate independent systems for each measurement.
3Adaptability or versatility
If multiple separate systems are used for screening and ablation, then functional versatility is improved, but the number of operations and patient damage are worsened
Solution Approach 1:
The patent applies universality by designing a single interventional catheter that integrates both the electrode element for neuromapping detection and the ablation element for radiofrequency ablation. This allows the same catheter to perform both screening (detection of nerve activity) and treatment (ablation) functions, eliminating the need for separate surgical procedures with separate catheters.
Solution Approach 2:
The patent merges the detection function and ablation function into a single integrated catheter system. The electrode element and ablation element are both positioned at the distal end of the same interventional catheter, allowing seamless transition from detection to treatment without requiring catheter removal or reinsertion, thereby reducing procedural complexity and patient trauma.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Accurately determines nerve activity levels and evaluates surgical effectiveness, enabling informed decision-making on the necessity of repeat procedures with minimal patient damage and using a single catheter for both screening and ablation.
Implementation Method 1
an electrode element, for releasing an electrical signal toward an inner wall of a renal artery blood vessel
Implementation Method 2
a pressure sensor for intervening to the renal artery blood vessel; monitoring a blood pressure change in said another renal artery blood vessel
Data Source
AI summary
The present application provides a preoperative detection method and a postoperative detection method for neuromapping, comprising releasing an electrical signal towards the renal artery blood vessel on one lateral side of the body of the patient by the electrode element; monitoring a heart rate by an electrocardiogram monitoring module, and monitoring a blood pressure change in said another renal artery blood vessel on the other lateral side of the body of the patient by the pressure sensor, and determining a nerve activity degree of the patient by judging whether the heart rate and the blood pressure change reach certain thresholds and making determinations in relation to the nerve activity degree so as to screen out the patients with an overactive sympathetic nerve, and a surgical effect of a denervation surgery can also be evaluated before or after the surgery, and can be used to determine whether to perform an ultrasonic ablation again.